Clinical Trial Protocols

Human African Trypanosomiasis

NECT-FIELD study - NCT00906880
Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine
(NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis
(HAT) in the Meningo-Encephalitic Phase (NECT-FIELD)
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Fexinidazole - NCT00982904
Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product,
the Fexinidazole
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Fexinidazole - NCT01340157
Fexinidazole (1200mg) Bioavailability Under Different Food Intake Conditions
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Fexinidazole - NCT01483170
Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food
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Efficacy - Safety of Eflornithine-Nifurtimox Combination - NCT00146627
Clinical Study Comparing the Nifurtimox-Eflornithine Combination With the Standard Eflornithine Regimen for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis in the Meningoencephalitic Phase
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Leishmaniasis

VL Combination Therapy in Asia

Comparison combination regimens vs. AmBisome Alone, Bangladesh - NCT01122771
Phase III, Study of Three Short Course Combination Regimens (Ambisome®, Miltefosine, Paromomycin) Compared With AmBisome® Alone for the Treatment of Visceral Leishmaniasis in Bangladesh
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Evaluation of different combination treatments, India - NCT00696969
Safety and Efficacy Study to Evaluate Different Combination Treatment Regimens for Visceral Leishmaniasis (India)
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Combination Therapy in Indian Visceral Leishmaniasis - NCT00523965
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VL Combination Therapy in Africa

Evaluation of different combination treatments, Eastern Africa - NCT01067443
Clinical Trial to Assess the Safety and Efficacy of Sodium Stibogluconate (SSG) and AmBisome® Combination, Miltefosine and AmBisome® and Miltefosine Alone for the Treatment Visceral Leishmaniasis in Eastern Africa 
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Dosage of Ambisome, Ethiopia - NCT00832208
Open-Label, Sequential Step, Safety and Efficacy Study to Determine the Optimal Single Dose of Ambisome for Patients With Visceral Leishmaniasis (Ethiopia)
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SSG vs PM vs SSG&PM - NCT00255567
Efficacy/Safety of Sodium Stibogluconate (SSG) Versus Paromomycin (PM) and SSG/PM Combination to Treat V Leishmaniasis (Ethiopia, Kenya, Sudan, Uganda)
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VL in Latin America

Comparison of Drugs for VL treatment in Brazil- NCT01310738
Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil (LVBrasil)
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Cutaneous Leishmaniasis

Imiquimod for Cutaneous Leishmaniasis - NCT00257530
Imiquimod Plus Antimony Immunochemotherapy for Cutaneous Leishmaniasis
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Chagas Disease

E1224 - NCT01489228
Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease
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