Filarial Diseases Research

 

  • Target disease: Filarial diseases
  • Funding: Bill & Melinda Gates Foundation, USA; Médecins Sans Frontières/Doctors without Borders, Department for International Development (DFID), UK.

 

Overall Objective:

  • Develop a third macrofilaricide candidate for filarial diseases.

 

Following a drug repurposing strategy, completion of screening of compounds against Onchocerca gutturosa and Onchocerca lienalis identified several hits and leads. Screened compounds have been provided by a number of pharmaceutical companies and belong to well-characterized chemical series which have been extensively optimized for other indications. Although the project was quite successful, none of the identified hits had the right profile to become a drug candidate for filarial diseases. Further lead optimization was thus undertaken in collaboration with industrial partners. These efforts will continue throughout 2017, with the aim of delivering a pre-clinical candidate for filarial diseases.

Last update: February 2017