Leishmaniasis Translation

 

  • Target disease: Visceral leishmaniasis
  • Main partners (since project start): Accelera, Italy; Anacor Pharmaceuticals Inc., USA; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Belgium; London School of Hygiene and Tropical Medicine, UK;  Sandexis, UK; Sara Pharm, Romania; Scynexis, USA; Syngene, India; Wil Research/Charles River, France; WuXi AppTech, China.
  • Project start: January 2010
  • Funding (since project start): Bill & Melinda Gates Foundation, USA; Department for International Development (DFID), UK; Federal Ministry of Education and Research (BMBF through KfW), Germany; Médecins Sans Frontières/Doctors without Borders, International; Swiss Agency for Development and Cooperation (SDC), Switzerland; Other private foundations and individuals.

 

Overall Objective:

  • Progress the pre-clinical development of DNDI-6148, a selected oxaborole for the treatment of leishmaniasis.

 

DNDi and Anacor have been working together over the last few years to identify oxaborole compounds, initially for the HAT programme, and this has expanded to include both leishmaniasis and Chagas disease. DNDI-6148 has emerged as a promising lead candidate for VL and CL and by the end of 2015 studies including exploratory toxicology necessary for possible progression to preclinical development had been successfully completed.

In January 2016, DNDI-6148, from the oxaborole class, was nominated as a pre-clinical candidate for the treatment of VL. Pharmaceutical development activities (drug substance and drug product development and manufacture) have now been initiated, and the toxicity/safety pre-IND package was launched starting with dose range finding studies, along with refinement of ADME (absorption, distribution, metabolism and elimination), efficacy and safety profile to ensure a smooth transition from the pre-clinical phase to Phase I clinical phase, which should happen over the course of 2017.

 

Last update: February 2017