Human African Trypanosomiasis Research

 

  • Target disease: HAT
  • Main partners (since project start): Anacor Pharmaceuticals Inc., Pace University, USA; The Laboratory of Microbioloy, Parasitology, and Hygiene, University of Antwerp, Belgium; SCYNEXIS Inc., USA.
  • Project start: April 2007 and April 2009, respectively
  • Funding (since project start): Bill & Melinda Gates Foundation, USA; Department for International Development (DFID), UK; Dutch Ministry of Foreign Affairs (DGIS), The Netherlands;  Federal Ministry of Education and Research (BMBF through KfW), Germany; Médecins Sans Frontières/Doctors without Borders, International; Spanish Agency for International Development Cooperation (AECID), Spain; Swiss Agency for Development and Cooperation (SDC), Switzerland; Other private foundations & individuals.

 

Overall Objective:

  • Maintain back-up oxaboroles which could replace the drug candidate SCYX-7158 in case it does not succeed in development.

 

Extensive pharmacokinetic profiling of possible oxaborole compounds led to the selection of SCYX-1608210 and SCYX‑1330682, which demonstrated cure in the stage 2 mouse model of HAT, as a backup for SCYX-7158 in case of need. Given the current success of other projects for HAT, further development was put on hold in 2013 and will only recommence should problems be encountered with SCYX-7158 in clinical development.

 

Last update: August 2016