Scientific Publications-2007-VL

2007

Kala-Azar Outbreak in Libo Kemkem, Ethiopia: Epidemiologic and Parasitologic Assessment by Alvar J, Bashaye S, Argaw D, Cruz I, Aparicio P, Kassa A, Orfanos G, Parreno F, Babaniyi O, Gudeta N, Canavate C, Bern C. Am J Trop Med Hyg. 2007 Aug; 77(2): 275-82.
In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemkem, Ethiopia. In October 2005, a rapid assessment was conducted using data from 492 patients with VL treated in the district health center and a household survey of 584 residents of four villages. Local transmission resulted from multiple introductions, is now well established, and will be difficult to eradicate.
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Consultative meeting to develop a strategy for treatment of cutaneous leishmaniasis. Institut Pasteur, Paris, 13–15 June, 2006 by Modabber F, Buffet PA, Torreele E, Milon G, Croft SL. Kinetoplastid Biol Dis. 2007 Apr 24; 6:3.
A meeting was organized by Drugs for Neglected Diseases initiative (DNDi) and the Institute Pasteur (IP), Paris, to review the treatment for all forms of cutaneous leishmaniasis (CL) and to propose a strategy for the development of new efficacious and affordable treatments. Short and long-term objectives and activities were defined as a part of meeting recommendations.
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Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis by Garnier T, Mantyla A, Jarvinen T, Lawrence MJ, Brown MB, Croft SL. J Pharm Pharmacol. 2007 Jan; 59(1):41-9.
As the part of a study to develop buparvaquone (BPQ) formulations for the treatment of cutaneous leishmaniasis, the topical delivery of BPQ and one of its prodrugs from a range of formulations was evaluated. The results confirm that BPQ and its prodrug 3-POM-BPQ can penetrate the skin from several formulations, making them potentially interesting candidates for further investigation of topical formulations using in-vivo models of cutaneous leishmaniasis.
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