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NECT (HAT)

 
 

NECT = Nifurtimox-Eflornithine Combination Therapy

NECT is the first new, improved treatment option in 25 years for stage 2 (advanced stage) human African trypanosomiasis (HAT) also known as sleeping sickness. It consists of a simplified coadministration of nifurtimox, which is given orally, and eflornithine, which is given intravenously.

  • Launched in 2009
  • Included in the Essential Medicines List (EML) of the WHO since 2009
  • Added to the Essential Medicines List for children of the WHO in 2013

  • Much safer than Melarsoprol, a highly toxic, arsenic-based drug that kills 5% of treated patients, still used in 50% of patients.
  • Compared to eflornithine monotherapy, the best previously available treatment for stage 2 HAT, NECT is:
    • As effective
    • Safer
    • Easier to administer
    • More cost-effective
    • Requests shorter hospitalisation
  • The result of a six-year partnership between NGOs, governments, pharmaceutical companies, and the WHO.
  • Donated by Sanofi and Bayer Schering Pharma AG
  • Available in 13 African countries that account for 100% of reported HAT cases
  • Represents 93% of HAT treatments distributed in DRC in 2011

Download NECT dossier in English [PDF 350KB]
Téléchargez le dossier NECT en français [PDF 317KB]
Read more about NECT project

  NECT News
Watch NECT video

On youtube!
- in English
- en français
Implementation progress
Available in 13 African countries

Request supply signed by Congo and Guinea
Recent Scientific Publications
PLOS NTDs, November 2012
In-Hospital Safety in Field Conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. b. gambiense Sleeping Sickness
Clinical Infectious Diseases, October 2012
Nifurtimox-Eflornithine
Combination Therapy (NECT) for second stage gambiense
human African trypanosomiasis: MSF experience in the Democratic Republic of
the Congo

 
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