Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria

A review by Olliaro PL, Taylor WR. J Postgrad Med, Jan-Mar 2004; 50(1):40-4.

Summary: The emergence and spread of drug resistant malaria represents a considerable challenge to controlling malaria. To date, malaria control has relied heavily on a comparatively small number of chemically related drugs, belonging to either the quinoline or the antifolate groups. Controlling resistance is key to ensuring that the investment put into developing new antimalarial drugs is not wasted. This review will summarise current antimalarial drug developments and outline recent clinical research that aims to bring artemisinin-based combinations to those that need them most.

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