Chemotherapy of trypanosomiases and leishmaniasis

by Croft SL, Barrett MP, Urbina JA. Trends Parasitol, November 2005, 21(11):508-12.

Summary: New formulations, therapeutic switching of the established drugs amphotericin B and paromomycin, and the serendipitous discovery of miltefosine have markedly improved leishmaniasis chemotherapy in the past 21 years. The situation for the two trypanosomiases has been less encouraging. However, the appearance of not-for-profit product-development partnerships offers a new paradigm for bringing new drugs to patients.

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