The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine

by Yardley V, Croft SL, De Doncker S, Dujardin JC, Koirala S, Rijal S, Miranda C, Llanos-Cuentas A, Chappuis F. Am J Trop Med Hyg, August 2005, 73(2):272-5.

Summary: Clinical isolates of Leishmania, from visceral leishmaniasis (VL) cases in Nepal and from cutaneous leishmaniasis (CL) cases in Peru, were cultured using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) to type species and strain. The study demonstrates a notable difference in the intrinsic sensitivity of Leishmania species to miltefosine in vitro.

Click here to download the full article [PDF]