Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum Malaria

by Ashley EA, Stepniewska K, Lindegardh N, McGready R, Hutagalung R, Hae R, Singhasivanon P, White NJ, Nosten F. Antimicrob Agents Chemother, July 2006, 50(7):2281-5.

Summary: A fixed artesunate-mefloquine combination, comprising three daily doses of 8 mg of mefloquine/kg of body weight and 4 mg of artesunate/kg, has been developed recently. This study was designed to construct a population pharmacokinetic model describing this new dosage regimen of mefloquine given as loose tablets together with artesunate. This new regimen is well tolerated and results in an equivalent therapeutic response.

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