Efficacy of artesunate-amodiaquine for treating uncomplicated P. falciparum malaria in Sub-Saharan Africa: a multi-centre analysis

by Zwang J, Olliaro P, Barennes H, Bonnet M, Brasseur P, Bukirwa H, Cohuet S, D’Alessandro U, Djimde A, Martensson A, Yeka A, Karema C, Guthmann J-P, Hamour S, Ndiaye J-L, Rwagacondo C, Sagara I, Same-Ekobo A, Sirima S, van den Broek I, Taylor W, Dorsey G, Randrianarivelojosia M. Malaria Journal, August 2009, 23(8):203.

Summary: This multi-centre analysis led by Julien Zwang at the Shoklo Malaria Research Unit addresses the efficacy of artesunate-amodiaquine, a very important candidate for the treatment of uncomplicated malaria globally. The analysis of patient-level data examining the efficacy of AS&AQ compared with local standard therapy, makes a strong case for the use of AS&AQ in all transmission settings. The analysis, sponsored by DNDi, has pooled data from 26 drug studies in a majority of paediatric malaria cases in sub-Saharan Africa identified through a systematic search and has focused on efficacy as safety will be reported separately. While not without limitations, this analysis contributes to the evidence base as to the proper use of ACTs, particularly the AS&AQ combination, and has provided results consistent with the recently published Cochrane systematic review and meta-analysis on ACTs (including AS&AQ.)

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