Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial

by Smithuis F, Kyaw Kyaw M, Phe O, Win T, Phyo Aung P, Pyay Phyo Oo A, Naing A L, Yee Nyo M, Htun Myint N Z, Imwong M, Ashley E, Lee S J, White N J. The Lancet Infectious Diseases, September 2010, 10(10):673 – 681.

Summary: The Artemisinin-combination therapy (ACT) is recommended as first-line treatment of P. falciparum malaria worldwide, and fixed-dose combinations are preferred by WHO. This study aimed to compare effectiveness of all four WHO-recommended fixed-dose ACTs (artesunate–mefloquine, artesunate–amodiaquine, dihydroartemisinin–piperaquine, artemether–lumefantrine) and a loose tablet combination of artesunate and mefloquine in Burmese adults and children. Artesunate–mefloquine provided the greatest post-treatment suppression of malaria.

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