Research & Development for Diseases of the Poor: A 10-Year Analysis of Impact of the DNDi Model

[Paris, France & Geneva, Switzerland – 5 December 2013]
Report provides real and estimated costs of repurposing drugs and new chemical entities, evoking the lessons learned based on alternative pathways and partnerships
Today, at a scientific meeting at Institut Pasteur, France, entitled ‘Best Science for the Most Neglected: Where Do We Stand Ten Years On?’, co-organized with Institut Pasteur and MSF and in collaboration with PLOS, the Drugs for Neglected Diseases initiative (DNDi) marks its 10-year anniversary by issuing a report that explores the lessons learned from a decade of research and development (R&D) of new treatments for neglected diseases via a cost-effective, innovative, not-for-profit drug development model. The report also comes at the time of discussions at the WHO aiming at gaining Member State agreement on ‘demonstration projects’ meant to provide evidence for the feasibility and sustainability of collaborative and open approaches to R&D for the health needs of developing countries.
[Deutsch] [Español] [Français] [Português]

New Collection from PLoS and DNDi highlights a decade of R&D into neglected tropical diseases

[Cambridge, UK – 27 November, 2013]
As part of a collaborative initiative, PLoS and the Drugs for Neglected Diseases initiative (DNDi) are delighted to be launching a special Collection—PLoS & DNDi: a decade of Open Access and Neglected Tropical Diseases R&D (Research and Development)—to coincide with a joint event at the Institut Pasteur in Paris celebrating the 10-year anniversary of DNDi.

Drug Trial for Leading Parasitic Killer of the Americas Shows Mixed Results but Provides New Evidence for Improved Therapy

[Washington, DC – 14 November, 2013]
First placebo-controlled study in adults with Chagas disease highlights urgent need to scale up treatment for millions of patients at risk
According to results of the first-ever Phase 2 clinical trial in Bolivia, conducted by the Drugs for Neglected Diseases initiative (DNDi), the experimental drug candidate E1224 showed good safety and was effective at clearing the parasite that causes Chagas disease, but had little to no sustained efficacy one year after treatment as a single medication. On the other hand, standard therapy for Chagas, benznidazole, was shown to be effective in the long term but continued to be associated with side effects. The results, presented today at the Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), highlight the need to investigate alternative dosing regimens and possible combination therapies to improve patient care.
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Mundo Sano and DNDi Join Forces to Provide Access to Treatments for Chagas Disease Patients

[Geneva, Switzerland – 11 November 2013]
Strategic agreement signed today to ensure crucial second source of pediatric formulation of benznidazole for millions of children in need of treatment
Today the Mundo Sano Foundation and the Drugs for Neglected Diseases initiative (DNDi) signed a wide-ranging accord to collaborate closely on a vital second source of the drug benznidazole for children affected by Chagas disease. From production to patient access, securing affordability and accessibility, the agreement unites the two not-for-profit organizations, highly involved in advocacy and drug research and development, in their common effort to fill treatment gaps for Chagas disease patients worldwide.
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Deadly Gaps Persist in New Drug Development for Neglected Diseases

[Geneva, Switzerland – 24 October 2013]
New study shows that, despite some progress, only 4% of new drugs and vaccines approved 2000-2011 were for neglected diseases, and a ‘fatal imbalance’ remains in R&D for many neglected patients
In a study published today in the open-access journal The Lancet Global Health, the Drugs for Neglected Diseases initiative (DNDi) and other researchers report a persistent deficiency in truly new therapeutics for neglected diseases, despite nominal progress and an acceleration in research and development (R&D) efforts. This continued ‘fatal imbalance’ in medical R&D points to the urgent need to develop and deliver groundbreaking new treatments for the world’s poorest and most neglected patients.
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UK Department for International Development (DFID) Commits £30 Million to DNDi

[Geneva, Switzerland – 22 August 2013]
5-Year Grant Awarded to DNDi to Advance Research and Development for Neglected Diseases
The UK Department for International Development (DFID) has announced its renewed support to the Drugs for Neglected Diseases initiative (DNDi), allocating a total of £30 million (€35 million) over the coming five years (2013-2018) to DNDi’s Research & Development (R&D) portfolio to fight neglected diseases. This grant is part of DFID’s larger investment of £ 138 million in nine product development partnerships (PPDs), including DNDi, for the development of new health tools to address poverty-related diseases.

The Swiss Agency for Development and Cooperation Reiterates Its Commitment to the Fight against Neglected Diseases

[Geneva, Switzerland – 30 July 2013]
The Swiss Agency for Development and Cooperation (SDC) recently renewed its support for the Drugs for Neglected Diseases initiative (DNDi), allocating a total of CHF 8 million over the coming four years (2013-2016). The research and development for new treatments for neglected diseases contributes to the World Health Organization’s global strategy to eliminate specific neglected tropical diseases by 2020.
[Deutsch] [Français]

Three Neglected-Disease Treatments Newly Added to WHO Essential Medicines List for Paediatric Use

[Geneva, Switzerland – 11 July 2013]
Resulting from DNDi’s paediatric R&D, the treatments will improve the management of deadly malaria, African sleeping sickness, and Chagas disease in children
This week the World Health Organization (WHO) released its newly updated 4th WHO Model List of Essential Medicines for Children (EMLc), in which three treatments developed by the Drugs for Neglected Diseases initiative (DNDi) and its partners have now been included. One treatment was also added to the 18th WHO Model List of Essential Medicines (EML) for adults.

DNDi & Cipla Advance Development of Paediatric 4-in-1 ARVs to Fulfill New WHO Guidelines

[Kuala Lumpur, Malaysia – 30 June 2013]
Immediate, Expanded, and Improved Treatments Needed for Infants and Toddlers with HIV
The World Health Organization’s new HIV treatment guidelines, released today at the 2013 International AIDS Society (IAS) Conference, include new antiretroviral (ARV) therapy (ART) recommendations for HIV-infected children, and will mean that more children will be on better treatments. The Drugs for Neglected Diseases initiative (DNDi) applauds the new guidelines and, with Cipla Ltd. and other partners, is expediting the development of urgently needed 4-in-1 ARVs adapted for babies and toddlers with HIV, to be delivered by 2015.

DNDi Receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation

[Madrid, Spain – June 18, 2013]
For those familiar with the field of neglected diseases, it goes by the name of the 10/90 gap: only 10 per cent of global health research was devoted to conditions that accounted for 90 per cent of the global disease burden. It was to counteract this imbalance that the Drugs for Neglected Diseases initiative (DNDi) came into being in 2003. Coinciding with its tenth anniversary year, the organization has been granted the BBVA Foundation Frontiers of Knowledge Award in the Development Cooperation category. Its Executive Director, Bernard Pécoul, announced this morning at a press conference that new drugs DNDi is working on “could dramatically change the management of some of these neglected diseases.”

Ten Years of Health Innovation in Africa: Progress Made But Sustained Engagement and Partnership Needed

[Nairobi, Kenya – 5 June 2013]
Days after two landmark resolutions were adopted at the World Health Assembly – on neglected tropical diseases and on research and development (R&D), financing and coordination for the health needs of developing countries – over 400 scientists, representatives and ministers of health, ambassadors, national control programme representatives, African regulators, health workers, public health experts, and activists from 21 African countries and 10 others from around the world gather in Nairobi to take stock of health innovation for neglected diseases in Africa over the past decade. While progress has been made, and certain diseases are targeted for elimination, the need for strong leadership, coordination, and sustainable funding is as pressing as ever and is critical to achieving much-needed breakthroughs.

Vote for DNDi! – Selected as Finalist for Rockefeller Foundation’s “Next Century Innovators Award”

[New York, NY, USA and Geneva, Switzerland – 2 May 2013]
Public Voting Underway Through May 31 – Finalist with Most Votes Will Receive Award
The Drugs for Neglected Diseases initiative (DNDi) was selected as one of two finalists for the Rockefeller Foundation’s “Next Century Innovators Awards”, recognizing innovative organizations working to improve conditions for vulnerable populations around the world.

Sanofi and DNDi celebrate six years of collaboration in fighting malaria

[Paris, France, and Geneva, Switzerland– 25 April 2013]
Sanofi (EURONEXT, SAN and NYSE;SNY) and the Drugs for Neglected Diseases initiative (DNDi), an independent not-for-profit foundation, announce that on the occasion of World Malaria Day, more than 200 million treatments of ASAQ Winthrop have been distributed in Africa since the medication became available in 2007.
[PDF] [Français]

International Consortium, To Bring New Treatments for Kala-Azar Patients in East Africa, Receives Funding Boost from European Union

[Geneva, Switzerland and Nairobi, Kenya – 23 April 2013]
Research and development (R&D) project, AfriCoLeish, is supported by the European Union Seventh Framework Programme (EU FP7) through a grant of €3 million. The project will run for three years and aims to test new treatments for kala-azar (visceral leishmaniasis, or VL) and co-infection of the disease with HIV in Ethiopia and Sudan.

Swiss Malaria Group announces winners of malaria photo contest

[Geneva, Switzerland – 22 April 2013]
On the occasion of World Malaria Day 2013, the Swiss Malaria Group announce the winners of the photo contest “Malaria: The Big Picture”. The online photo contest and subsequent exhibition was organised by the Swiss Malaria Group to highlight the reality of those living at risk of malaria and the work of those dedicated to changing that reality.
[Click here to view the winning photos from each category][Français] [Deutsch]

Chagas specialists from around the world have gathered in Cochabamba, Bolivia to discuss projects to improve the health and quality of life of those affected by Chagas disease

[Cochabamba, Bolivia – 16 April 2013]
“Chagas Week: Neglected Disease” gathers doctors, specialists, researchers and authorities to discuss issues related to the disease that affects up to 8 million people worldwide, mostly in Latin America, according to the World Health Organization.
[PDF][Español] [Português]

DNDi Latin America Pledges 2013 Carlos Slim Health Award to Chagas Disease

[Mexico City – 10 April 2013]
This silent killer urgently needs a coordinated response and action plan
The Drugs for Neglected Diseases initiative (DNDi) Latin America today announced that it will pledge the US $100,000 Carlos Slim Health Award to Chagas disease, the leading parasitic killer of the Americas..

DNDi welcomes the Global Health Innovative Technology Fund (GHIT Fund), a new Japan-driven initiative to accelerate research & development innovation for neglected diseases

[Tokyo, Japan, and Geneva, Switzerland – 8 April 2013]
New Japan-Driven Initiative to Accelerate Research & Development Innovation for Neglected Diseases
The Drugs for Neglected Diseases initiative (DNDi), based in Geneva, Switzerland, and DNDi Japan, based in Tokyo, welcome the launch of the Global Health Innovative Technology Fund (GHIT Fund), an initiative supported by the Japanese government, several Japanese pharmaceutical companies, and the Bill & Melinda Gates Foundation. [Japanese – in pdf]

DNDi Receives BBVA Foundation Award for Development Cooperation

[Geneva, Switzerland – 26 February 2013]
Today in Madrid, Spain, the Drugs for Neglected Diseases initiative (DNDi) received the BBVA Foundation ‘Frontiers of Knowledge and Culture Award for Development Cooperation’. This EUR 400,000 award will be presented at a ceremony in Madrid, Spain, in June of this year.