Translational challenges of animal models in Chagas disease drug development: A review

by Chatelain E and Konar N. Drug Design, Development and Therapy, 2015, doi:

Summary: Animal models available for Chagas disease have limited predictive value for the preclinical evaluation of novel therapies. This review highlights the overall lack of standardized methodology and assessment tools, which has hampered the development of efficacious compounds to treat Chagas disease. We provide an overview of animal models for Chagas disease, and propose steps that could be undertaken to reduce variability and improve predictability of drug candidate efficacy. New technological developments and tools may contribute to a much needed boost in the drug discovery process.

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