Global Antibiotic Research and Development Partnership
[Closing date: 14 August 2016]
WHO and the Drugs for Neglected Diseases initiative have collaborated over the past two years on the creation of a Global Antibiotic Research and Development Partnership, a not for profit research and development organization, to develop new antibiotic treatments addressing antimicrobial resistance and to promote their responsible use for optimal conservation, while ensuring equitable access for all. DNDi has agreed to facilitate the set up and hosting of the partnership and provide the scientific environment, necessary personnel and infrastructure to ensure an effective incubation period. GARD will work closely with all stakeholders in the field of antibiotic research and development (R&D) – including pharmaceutical and biotechnology companies, startups, other product development partnerships, academia, civil society, and health authorities – from countries of all income levels to develop new antibiotic treatments, with the aim of becoming an independent organization within a period of two years.
Ultimately, GARD will:
- address global public health and specific needs of low- and middle-income countries, targeting products that industry will not develop due to lack of profitability;
- pilot the use of alternative incentive models that support conservation of and access to new antibiotics based on DNDi’s experience in implementing alternative R&D models for neglected diseases;
- ensure that new antibiotics are affordable to all.
The AMRi project
One of the key start-up projects that GARD is currently preparing for launch by the end of the year is the Antibiotic Memory Recovery initiative (AMRi). AMRi aims to identify, compile, and openly share know-how, information and assets from existing resources – human, electronic, and material – within an open access platform in order to stimulate and enhance the antibiotic drug discovery and development ecosystem at large by:
- Identifying researchers and drug developers active, or that were active in the field of antibiotic R&D that hold specific memory of forgotten, withdrawn, or abandoned antibiotics, and establishing a publicly available, online database.
- Recovering and archiving published (including patent searches) and whenever possible unpublished data from forgotten, withdrawn, or abandoned antibiotics, including in priority pharmaceutical companies’ stalled projects, or compounds shelved due to mergers or closures.
- Identifying and ultimately bringing together relevant molecule collections (structures, materials, compounds, and reagents) which could potentially be resynthesized where necessary and shared in an ‘antibiotic memory box’ to research groups, along data, key individuals involved, and any new information generated by others in an open source manner
- Evaluate and scope for specific collaborations with relevant entities in order to accelerate R&D of the most relevant AMRi compounds according to GARD’s mandate
Senior Project Manager Responsibilities:
- Build and drive the project and its workstreams with an external consultant (initiator of AMRi)
- Research and build a solid network of active and retired antibiotic drug discovery and development experts worldwide
- Organize and manage the experts group so as to maximize the benefits for the anti-infective community and GARD’s activities
- Research and build a historical list of companies that have worked on antibiotics
- Propose innovative sub-projects to be proposed for utilizing any available or recovered data and assets
- Build and maintain appropriate database of assets
The successful applicant will:
- Have a solid understanding of modern drug discovery and development in the pharmaceutical industry with extensive experience in contributing to and managing complex projects.
- Have solid experience and contacts in the field of antibiotics
- Have solid experience in database management tools, including database programming abilities, and possess broad IT competencies
- Have excellent project management skills and ability to drive the project with many external partners
- Have excellent (face to face, tele/videoconference, email) communication and presentation skills and be capable of meeting challenging timelines for the AMRi
- Be reliable, organized, and detail-orientated
- Have ability to work independently as well as a good team player
- Have ability to work in a fast-paced environment, sometimes under pressure
- Have experience working in international environment and with people from different cultural backgrounds
The AMRi Senior Manager reports to the Director of Business Development and works closely under the guidance of both the project initiator and the Chair of the GARD Scientific Advisory Group, both consultants.
Location and travel:
- The position is based in Geneva and involves regular international travel to meet our partners.
- This is a new 1.0 FTE contract position from 1 October 2016.
- For additional information about DNDi please visit our website at www.dndi.org/GARD.
- Accepting applications until 14 August 2016.
- Only shortlisted candidates will be contacted.