Towards elimination of visceral leishmaniasis in the Indian subcontinent – Translating research to practice to public health

by Hirve S, Kroeger A, Matlashewski G, Mondal D, Banjara MR, Das, P, Be-Nazir A, Arana B, Olliaro P. PLOS Neglected Tropical Diseases 2017, doi: 10.1371/journal.pntd.0005889

Summary: This review describes the engagement and contribution of the Special Programme for Research and Training in Tropical Diseases (TDR) in the VL elimination initiative in the Indian subcontinent. Multiple databases were searched to identify 152 scientific papers and reports with WHO funding or authorship affiliation around the 3 framework strategies: detection of new cases, morbidity reduction, and prevention of infection. TDR has played a critical role in the evaluation and subsequent use of the rK39 rapid diagnostic test; supported clinical research and development of miltefosine and single-dose liposomal amphotericin B; engaged with stakeholders to generate evidence-based interventions for early detection and treatment; and evaluated the quality, community acceptance, and cost effectiveness of various tools for integrated vector management.

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