Synergic effect of allopurinol in combination with nitroheterocyclic compounds against Trypanosoma cruzi

by Mazzeti AL, Diniz LDF, Gonçalves KR, WonDollinger RS, Assíria T, Ribeiro I, Bahia MT. Antimicrobiol Agents and Chemotherapy 2019, 63: e02264-18. doi:10.1128/AAC.02264-18

Summary: This study evaluated the effects of allopurinol in association with nitro compounds on infection with Y strain Trypanosoma cruzi in order to determine whether allopurinol might be useful as part of a combination therapy for Chagas disease. A synergistic interaction was found for allopurinol with both nifurtimox and benznidazole in vitro. Administration of allopurinol and benznidazole in combination significantly increased the cure rate to 60 to 100% in infected Swiss mice treated with benznidazole 75 mg/kg plus 30, 60, or 90 mg/kg allopurinol. These results show a positive interaction between allopurinol and benznidazole and, since both drugs are commercially available, their use in combination may be considered for evaluation in the treatment of Chagas disease patients.

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