Biomarkers in post-kala-azar dermal leishmaniasis

by Zijlstra EE. Frontiers in Cellular and Infection Microbiology 2019, 9:228. doi: 10.3389/fcimb.2019.00228

Summary: Post-kala-azar dermal leishmaniasis is an asymptomatic skin rash that follows visceral leishmaniasis in 10–60% of cases. Diagnosis is difficult in the field and is often made clinically. Response to treatment is difficult to assess, as this may be slow and lesions take a long time to heal, thus possibly exposing patients unnecessarily to prolonged drug treatment. Biomarkers are needed to improve diagnosis and response to treatment. In this paper, the authors review evidence for currently used biomarkers and discuss promising developments.

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