R&D Portfolio Update February 2019: DNDi Leishmaniasis programme

Leish patients in a hospital

In Africa, results of a Phase III study on HIV/VL in Ethiopia showed high efficacy of a new combination therapy for co-infected patients, a Phase III study began to test new combination treatment for visceral leishmaniasis, and a Phase II study testing new treatments for PKDL started in Sudan. In Asia, the results of an infectivity study in Bangladesh confirmed that PKDL acts as a reservoir for leishmaniasis infection, with implications for elimination efforts across South Asia. In Latin America, the Brazilian Ministry of Health is reviewing its treatment policy to consider the adoption of AmBisome as the country’s first-line visceral leishmaniasis treatment.

R&D Portfolio Update February 2019: DNDi Chagas disease programme

Chagas patient in the hospital with a nurse

A Phase II study of new benznidazole regimens was completed in 2018 with results coming in 2019. A Phase II study of fexinidazole, a new drug being tested for Chagas, completed patient recruitment in 2018. New diagnosis and treatment access projects were launched in Guatemala and Brazil, and the project in Colombia showed major increases in people tested in pilot areas.

R&D Portfolio Update February 2019: DNDi Mycetoma programme

Mycetoma patients sitting in front of a hospital

The first-ever double-blind, randomized clinical trial for fungal mycetoma, underway in Sudan, had enrolled 84 patients by January 2019, the threshold for interim analysis. The primary objective of the study is to demonstrate the superiority of fosravuconazole over the current standard, itraconazole.  

R&D Portfolio Update February 2019: DNDi Paediatric HIV programme

Little boy with paediatric HIV being measured by a nurse in a hospital

As development continues for a “4-in-1” fixed-dose combination (abacavir/lamivudine/ lopinavir/ritonavir) for young children, interim results of the LIVING study for an optimized “2-in-1” lopinavir/ritonavir paediatric formulation were released. The study – which enrolled over 1,000 children in sub-Saharan Africa – showed that 83% of children were virologically suppressed at 48 weeks, compared to 55% at the beginning of the study.

R&D Portfolio Update February 2019: DNDi Hepatitis C programme

HCV patient standing in the street

The first stage of the clinical trial in Malaysia and Thailand testing the ravidasvir/sofosbuvir combination showed excellent results in 301 chronically infected adults, as 97% of those enrolled were cured. Cure rates were notably high for the hardest-to-treat patients. Stage 2 of the study, to confirm the pangenotypic potential of the combination, has started.

DNDi endorses the global Call for Action to step up the fight against mycetoma

Mycetoma Call for Action signed at the Mycetoma Conference in Sudan

DNDi has joined partners from 35 countries attending the Sixth International Conference on Mycetoma in Khartoum, Sudan to endorse a ‘Call for Action’ to accelerate global efforts to address the plight of mycetoma patients. The Call for Action urges the global health community to work together with health ministries, multilateral agencies, research institutions, pharmaceutical companies, and other partners to address the devastating consequences of this highly neglected disease.

An HIV/VL patient’s long road to better treatment

Man sitting on a bed in a hospital

Nigatu Abebe from Ethiopia sits on a bed in the Leishmaniasis Research and Treatment Centre (LRTC) at the University of Gondar in Ethiopia. He looks very frail and has been battling against visceral leishmaniasis (VL), also known as kala-azar, and HIV for 11 years.

2018 in Review

Dr Kande in DRC screening patients in a village

2018 showed us that another way to develop life-saving drugs is possible. Travel the globe with us to see how 15 years of patient-focused research and development (R&D) are bearing fruit for the most neglected patients.

Making Medical History

More than 180 friends, supporters, partners, celebrities, and global health influencers celebrated our 15-year anniversary with us at our Making Medical History Gala in New York City.

Inaugural DNDi training for health & science journalists in Kampala

In early October, 18 journalists from 11 African countries converged in Kampala, Uganda for DNDi’s first-ever training on health and science journalism. The three-day training was conducted during a week of workshops and meetings related to the work of DNDi and its many partners, culminating in the 11th DNDi Partners’ Meeting on 4 October 2018.

Malaysia takes the lead on a public health approach to hepatitis C with new initiative to enhance diagnosis & treatment

Doctor in a hospital in Malaysia

New agreement between Clinical Research Malaysia & FIND on R&D for hepatitis C diagnostic tests continues an existing Malaysian partnership with DNDi for hepatitis C treatment

The Foundation for Innovative New Diagnostics (FIND) and Clinical Research Malaysia (CRM), both DNDi partners, recently signed a memorandum of understanding (MoU) to collaborate in the research and development of an innovative hepatitis C diagnostic testing strategy.

DNDi announces new Director of Neglected Tropical Diseases

Dr Nathalie Strub-Wourgaft examines patient in Sudan.

Former DNDi Medical Director Dr Nathalie Strub-Wourgaft takes over leadership of NTD programme

DNDi is pleased to announce the appointment of Dr Nathalie Strub-Wourgaft as the new Director of Neglected Tropical Diseases. She will assume her new role as NTD Director and member of DNDi’s Executive Team as of 1 July 2018.

Ending the neglect of Chagas

Landscape of ColombiaHidden in the mountains, forests, and pastures of the central Andean region in Colombia are small, remote communities where Chagas disease still takes a heavy toll.

Revealing the Neglect: Chagas Disease

Yerko grew up in Bolivia in the small community of El Forestal in the east of the country. As a child, he and his family lived in a house with walls made of adobe bricks and a roof of palm leaves. Hidden inside the cracks and crevices in the walls and roof were kissing bugs. Yerko wanted to become a pharmacist to help people in need, but became a victim of Chagas disease.