DNDi passes the ball to MMV

DNDi Executive Director Bernard Pécoul passes a rugby ball to David Reddy, Chief Executive Officer of MMV, to symbolise the handing over of the DNDi malaria treatments ASAQ and ASMQ to MMV

Two fixed-dose artemisinin combination therapies (ACTs) developed by Drugs for Neglected Diseases initiative (DNDi) and partners, artesunate-amodiaquine (ASAQ) and artesunate-mefloquine (ASMQ), will now be managed by MMV’s Access and Product Management team to help maximize their impact for the patients who need them most.

Close-up on Paediatric HIV

[30 April 2015]

An estimated 3.3 million children under 15 years of age were living with HIV worldwide in 2012. During that one year alone, some 260,000 children were infected with HIV (over 90% of these were in sub-Saharan Africa). A further 210,000 died of the disease, the vast majority before reaching the age of two and without having been diagnosed. Most of these deaths could have been avoided had diagnosis been carried out in the first weeks of infection and treatment immediately commenced.  While the absolute number of infants newly infected with HIV is now declining due to international efforts made in prevention of mother to child transmission, the need for paediatric treatment will continue to increase at least until 2020.

Chagas Disease in Colombia: An opportunity to lead the way towards change

Rafael VilasanjuanRafEric Stobbaertsael Vilasanjuan, ISGlobal and Eric Stobbaerts, DNDi Latin America – members of the Global Chagas Disease Coalition
[April 2015]

During the month that celebrates International Chagas Disease day, Colombia, via its Ministry of Health has confirmed its commitment to the disease, a reason for optimism for the entire region. Aware of the difficulty of access to diagnosis and treatment (less than 1,000 patients treated), an action plan has been proposed to tackle Chagas Disease under the leadership of the Ministry of Health and Social Protection. A model project supported by DNDi and capable of being implemented in other locations arose as an example and brings hope not only to the 437 thousand infected persons and roughly 4.8 million people at risk of being infected in the country, but also for other affected countries.
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DNDi congratulates team of researchers at University Hospital Bonn, which has received the Memento Research Award 2015 for their commitment against neglected diseases

The Drugs for Neglected Diseases initiative congratulates the team of researchers at the University of Bonn-Hospital for the Memento Research Award 2015. The research group of Prof. Achim Hörauf from the University of Bonn has received this prize awarded by a group of NGOs for their research into the development of  a therapy for the neglected disease `lymphatic filariasis`.

Will Crisis See a Long-Awaited Response to Lack of Innovation and Access Come from Public Leadership?

Bernard PécoulBernard Pécoul, Executive Director, DNDi
[February 2015]

While the epidemic peak of the Ebola crisis slightly begins to wane and with it potential avenues for treatment beginning to emerge, the global health community simply cannot go back to business as usual. A strong public opinion has been mobilized and with Ebola now a household term, there is simply no turning back. A hard stance is being taken on many fronts, including policy makers, scientists, pharmaceutical companies, philanthropists, civil society members, global health experts, and journalists to ensure that beyond this one crisis, the lessons learned from several hitherto seemingly unrelated public health issues be brought together and examined with the same scrutiny. But we cannot stop there; a comprehensive and lasting solution could be at our doorsteps but requires a serious look at what is not working currently, and what is!

DNDi joins forces with leading organizations to tackle the deadly tropical disease, Visceral Leishmaniasis

The Consortium for the Control and Elimination of Visceral Leishmaniasis, known as KalaCORE, is a new partnership between the Drugs for Neglected Diseases initiative, the London School of Hygiene and Tropical Medicine, Médecins Sans Frontières and Mott MacDonald. The consortium has been appointed by the Department for International Development (DFID) to tackle Visceral Leishmaniasis (VL) in South Asia and East Africa.

Strengthening the Malaria Treatment Arsenal for Children in Africa

Dr Bernhards OgutuDr Sodiomon SirimaDr Bernhards Ogutu, KEMRI, Kenya and Dr Sodiomon Sirima, CNRFP, Burkina Faso
[November 2014]

Today, we have results of a large clinical trial conducted in three countries across both East and West Africa by DNDi in partnership with the Central National de Recherche et de Formation sur le Paludisme (CNRFP) in Burkina Faso, the Kenya Medical Research Centre (KEMRI) in Kenya, the National Institute for Medical Research (NIMR), and the Ifakara Health Institute in Tanzania. ASMQ (artesunate-mefloquine) fixed dose combination (FDC) has proven safe and efficacious in treating children with uncomplicated P. falciparum malaria in Africa, and is non-inferior to artemether-lumefantrine (AL).

Learning to deliver: Challenges in NTD drug research and development

Graeme BilbeDr Graeme Bilbe, Research & Development Director, DNDi
[September 2014]

DNDi and other not-for-profit drug research and development (R&D) organizations have explored new R&D pathways to develop and deliver safe, adapted, and affordable treatments for neglected diseases. Most of these new pathways have shown signs of success, while several have faced challenges that span across the drug discovery and development processes.

R&D status September 2014: DNDi Leishmaniasis programme

[September 2014]

Leishmaniasis is transmitted by the bite of a sand fly. It is a complex disease with over a million new cases occurring every year and 350 million people living at risk worldwide in 98 countries. The disease presents several different forms, the most common of which are visceral leishmaniasis (VL), which is fatal without treatment, and cutaneous leishmaniasis (CL).

R&D status September 2014: DNDi Filarial diseases programme

[September 2014]

Filarial diseases include onchocerciasis (also known as River Blindness), lymphatic filariasis (also known as elephantiasis), and loiasis. They are caused by parasitic worms which are transmitted by insect vectors to humans, mainly in Africa and Southeast Asia. About 168 million people are infected by the three diseases.

R&D status September 2014: DNDi Sleeping Sickness programme

[September 2014]

Human African trypanosomiasis (HAT), also known as ‘sleeping sickness’, is transmitted by the tsetse fly. While currently its prevalence is declining, HAT is still a threat to millions of people across Sub-Saharan Africa with 83% (2013) of all cases in the Democratic Republic of Congo (DRC).

R&D status September 2014: DNDi Malaria programme

[September 2014]

Malaria is transmitted by mosquitoes. It kills one child every 30 seconds in sub-Saharan Africa and is the leading parasitic cause of morbidity and mortality worldwide. 3.2 billion people are at risk. DNDi with its partners have delivered two fixed-dose combination (FDC) of the five artemisinin-based drugs (ACTs), FDC’s that were recommended by WHO for the treatment of uncomplicated falciparum malaria.

Conducting clinical trials for sleeping sickness in remote areas of the Democratic Republic of the Congo – Overcoming Operational Challenges and Reaping Health System Benefits

Wilfried MutomboDr. Wilfried Mutombo, Coordinating investigator, Fexinidazole study for HAT
[July 2014]

At the time DNDi and its partners are extending the clinical trial on fexinidazole, the first new oral treatment tested for sleeping sickness, to the early stages of the disease in adults and to children between 6 and 14 years of age, it is important to remember how clinical trials in remote areas of a country such as the Democratic Republic of the Congo (DRC) can be a daunting challenge, but can also bring lasting benefits to local communities and researchers, and to the health system overall.