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Effective treatments exist, but there are limitations:
- Widespread drug resistance: chloroquine, one of the easiest to use and most available malaria treatments, is no longer effective, with parasite resistance at more than 90% in some parts of the world
- Existing combination therapies, now adopted as first-line treatment in most malaria-endemic countries, can be expensive and have complicated treatment regimens
- Limited access of neglected patients to the few paediatric strength, fixed-dose ACTs which are available
- The countries suffering the most from malaria lack the necessary capacity and funding to deliver the drugs to the patients who need them.