Leishmaniasis Translation

 

  • Target disease: Visceral leishmaniasis
  • Main partners (since project start): Takeda Pharmaceutical Company Ltd, Japan
  • Project start: March 2018 (for 2 years)
  • Funding (since project start): GHIT (Takeda recipient)

 

Overall Objective:

  • Progress DNDi-5561, a selected aminopyrazole compound, to Phase I clinical trials and realize some activities including formulation development, drug product manufacture and start single ascending dose stage of first-in-human.

 

This project is the continuation of the optimization of the aminopyrazole series for visceral leishmaniasis project. DNDi and Takeda worked with the objective of delivering an anti-parasitic aminopyrazole drug that could meet the Target Product Profile (TPP) published by DNDi. A lead second generation compound DNDI-5561 and several additional advanced, and differentiated, second generation leads have been identified that could provide differentiated back-ups.

 

Following positive results of efficacy and safety studies in animal model, DNDI-5561 was selected as pre-clinical candidate.

 

Last update: April 2018