Following proof-of-principle with the 205 series for visceral leishmaniasis, compounds from this series have shown a 100% parasite load reduction in liver and spleen in a visceral leishmaniasis murine model. Further characterization of this series is ongoing.

Project updates

2019

Following the assessment of the three lead compounds from this series (DNDI-6588, DNDI-6749, and DNDI-6174), DNDI-6174 was progressed and nominated as a pre-clinical candidate for visceral leishmaniasis.

2018

Lead compound DNDI-6588 showed great efficacy in vivo in both mouse and hamster models for visceral leishmaniasis. Additional 205-series compounds having similar or improved profiles have been added to the candidate shortlist and are currently being assessed.

2017

Over 400 compounds have been synthesized to date in this lead optimization programme for Chagas disease and leishmaniasis.