- Target disease: HAT
- Main partners (since project start): Anacor Pharmaceuticals Inc., USA; Advinus Therapeutics Ltd, India; SCYNEXIS Inc., USA; Avista Pharma (formerly SCYNEXIS), USA; Swiss Tropical and Public Health Institute, Switzerland; Institute of Tropical Medicine Antwerp, Belgium; Institut de Recherche pour le Développement, France; Institut National de Recherche Biomédicale, DRC.
- Project start: January 2010
- Funding (since project start): Bill & Melinda Gates Foundation, USA; Department for International Development (DFID), UK; Dutch Ministry of Foreign Affairs (DGIS), the Netherlands; Federal Ministry of Education and Research (BMBF through KfW), Germany; Médecins Sans Frontières/Doctors without Borders, International; Norwegian Government, Norway; Spanish Agency for International Development Cooperation (AECID), Spain; Swiss Agency for Development and Cooperation (SDC), Switzerland; BBVA Foundation, Spain; Other private foundations and individuals.
An oxaborole originally provided by Anacor Pharmaceuticals was found to be active against HAT parasites at the University of California San Francisco, and further investigated by a consortium consisting of DNDi, Anacor, SCYNEXIS, Pace University, and Swiss TPH. Compound optimization over two years and examination of over 1,000 compounds produced SCYX-7158 which was selected as a promising pre-clinical candidate for g-HAT in late 2009. In pre-clinical studies, SCYX-7158 was shown to be safe and efficacious in treating a brain form of the disease in animals, when administered orally in a single dose. In March 2012, SCYX-7158 became DNDi’s first new chemical entity resulting from its own lead optimization programme, to enter clinical development. SCYX-7158 was found to have an unusually long half-life when tested in healthy volunteers.
A pivotal Phase II/III trial started in the last quarter of 2016. Seven study sites – Katanda, Isangi, Dipumba, Ngandajika, Masi Manimba, Kwamouth, and Bolobo – were initiated in Democratic Republic of Congo (DRC). 11 patients (out of a target 350) had been recruited by the end of 2016.
Last update: February 2017