- Target disease: Paediatric HIV
- Main partners (since project start): Cipla, India; Department of Health, South Africa; Medical Research Council, UK; UNITAID; Centre for Disease Control and Prevention (CDC)/President’s Emergency Plan for AIDS Relief, USA; Médecins Sans Frontières; Necker Institute, France; various academic partners in South Africa and Kenya; AbbVie, USA; WuXi AppTech, China.
- Project start: 2012
- Funding (since project start): French Development Agency (AFD), France; Médecins Sans Frontières/Doctors without Borders, International/Norway; Spanish Agency for International Development Cooperation (AECID), Spain; Swiss Agency for Development and Cooperation (SDC), Switzerland; UNITAID, Switzerland.
Pharmacokinetic modelling was carried out to determine drug dosages within potential 4-in-1 formulations, and the proposed dosing for the two 4-in-1 LPV/r based FDCs and RTV booster were incorporated into Annex 7 of the WHO’s new Consolidated Guidelines on The Use of Antiretroviral Drugs for Treating and Preventing HIV Infection, under ‘urgently needed ARV drugs for children recommended by the Paediatric ARV Working Group’ in 2013.
New formulations of LPV/r pellets are required to optimize bioavailability and taste-masking, but this has proved to be very challenging.
Last update: February 2017