Preliminary results of a Phase II study evaluating new therapeutic regimens of benznidazole showed that all treatment arms were effective and had good safety profiles. The two-week course of treatment with benznidazole alone was particularly promising, showing 83% efficacy while cutting treatment time by 75% compared to the standard eight-week treatment, with no patients discontinuing treatment due to side effects. Based on these results, DNDi is planning to run an international, multi-site confirmatory Phase III study.
- The IS Global XVI Workshop on Chagas disease has been cancelled.
by Zrein M, Chatelain E.
BBA – Molecular Basis of Disease, December 2019
Brazilian Society of Tropical Medicine [9 December 2019]
“International consortium seeks development of new drugs for neglected diseases and malaria”
Brasilia, Brazil – 5 December 2019
Studies may lead to therapeutic alternatives for people living with these neglected tropical diseases
The Brazilian Ministry of Health (the Department of Science and Technology of the Science, Technology and Strategic Inputs Secretariat – Decit/SCTIE) and CNPq (National Council for Scientific and Technological Development) will invest around R$ 1,5 million (US$ 370,000) in research that may lead to the development of a new treatment option for cutaneous leishmaniasis.
by Pinazo MJ, Pereiro A, Herazo R, Chopita M, Forsyth C, Lenardon M, Losada I, Torrico F, Marchiol A, Vera M.
Acta Tropica, December 2019
DNDi, in partnership with the Mexican National Centre for Disease Prevention and Control (CENAPRECE) and the Veracruz Programme for Prevention and Control of Vector Transmitted Diseases, is holding a seminar in Veracruz, Mexico, aimed at identifying the main barriers to comprehensive care for people living with Chagas disease.
São Paulo – 27 November 2019
In the search for new drugs to treat neglected diseases and malaria, researchers at the University of Campinas (UNICAMP) and University of Sao Paulo will assemble a team of scientists in a global collaboration network co-funded by the São Paulo Research Foundation, DNDi, and the Medicines for Malaria Venture.
by Koovits PJ, Dessoy MA, Matheeussen A, Maes L, Caljon G, Mowbray CE, Kratz JM, Dias LC.
Bioorganic & Medicinal Chemistry Letters, October 2019
The Huffington Post [23 October 2019]
“Cory Booker introduces new bill to combat diseases of extreme poverty”
68th Annual Meeting
20-24 November 2019
National Harbor, USA
- Symposium on tools to accelerate elimination of onchocerciasis
- Presentations on onchocerciasis, lymphatic filariasis, leishmaniasis, clinical trials, and Chagas disease.
by Batista C, Forsyth CJ, Herazo R, Certo MP, Marchiol A.
Pan American Journal of Public Health, September 2019
New York/Los Angeles – 26 September 2019
New DNDi/CECD/MSF paper published in PLOS Neglected Tropical Diseases on the “silent killer” Chagas disease
Fear, stigma, gaps in the health system, and lack of awareness in the medical community are among the barriers keeping the most vulnerable from accessing essential care for Chagas disease, a leading cause of heart disease in the Americas, according to a paper published today by the not-for-profit drug development organization DNDi, the Center of Excellence for Chagas Disease, and the international medical humanitarian organization MSF.
Nueva York/Los Ángeles – 26 September 2019
Nuevo artículo de DNDi/CECD/MSF publicado en PLOS Neglected Tropical Diseases sobre la enfermedad de Chagas, “el asesino silencioso”.
El miedo, las brechas en el sistema de salud y la falta de concientización son algunas de las barreras que impiden el acceso de los más vulnerables al tratamiento de la enfermedad de Chagas, una de las principales causas de problemas cardíacos en las Américas, según un artículo publicado por la organización sin fines de lucro de desarrollo de medicamentos iniciativa Medicamentos para Enfermedades Olvidadas (DNDi, por su acrónimo en inglés), el Center of Excellence for Chagas Disease (CECD) del centro médico Olive View de la UCLA y la organización humanitaria médica internacional Médicos Sin Fronteras (MSF).
by Forsyth C, Meymandi S, Moss I, Cone J, Cohen R, Batista C.
PLOS Neglected Tropical Diseases, September 2019
This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment.
SpringerLink, September 2019
La Nacion [22 August 2019]
“Enfermedad de Chagas: la transmisión materna ya origina más casos que la vinchuca” – “Chagas disease: congenital transmission already is the source of more cases than the vinchuca”
by Hennig K, Abi‑Ghanem J, Bunescu A, Meniche X, Biliaut E, Ouattara AD, Lewis MD, Kelly JM, Braillard S, Courtemanche G, Chatelain E, Béquet F.
Metabolomics, August 2019