O Tempo [14 March 2019]
“Tratamento ajuda pacientes com doença de Chagas” – “Treatment helps patients with Chagas disease”
O Globo [14 March 2019]
“Tratamento mais curto para doença de Chagas pode ter mesma eficácia e ser mais seguro” – “Shorter treatment for Chagas disease could have same effectiveness and be safer”
Estadão [14 March 2019]
“Estudo reduz tempo de uso de remédio contra doença de Chagas e facilita tratamento” – “Study reduces treatment lenght for Chagas disease and facilitates treatment”
El País [14 March 2019]
“Acabar con el parásito con la mitad de pastillas” – “Ending the parasite with half the pills”
The Telegraph [14 March 2019]
“New treatment brings hope to those bitten by the ‘kissing bug'”
Barcelona/Rio de Janeiro – 14 de março de 2019
Os resultados podem ajudar a eliminar uma das barreiras à implementação do tratamento em larga escala e renovar as esperanças para as pessoas com doença de Chagas
Um tratamento com duração de apenas duas semanas para pacientes adultos com doença de Chagas crônica demostrou, comparado com placebo, ter eficácia semelhante e efeitos colaterais significativamente menores do que o tratamento padrão com duração de oito semanas, de acordo com os resultados de um estudo clínico realizado na Bolívia sob a coordenação da iniciativa Medicamentos para Doenças Negligenciadas (DNDi).
Barcelona/Río de Janeiro – 14 de marzo de 2019
Los resultados pueden ayudar a eliminar una de las barreras para ampliar el tratamiento y aportan esperanza a los pacientes con Chagas
Un tratamiento de dos semanas para pacientes adultos con Chagas crónico muestra, comparado con placebo, una eficacia similar y un número significativamente menor de efectos adversos que el tratamiento estándar de ocho semanas de duración, según los resultados de un ensayo clínico en Bolivia, liderado por la iniciativa “Drugs for Neglected Diseases” (DNDi).
Barcelona/Rio de Janeiro – 14 March 2019
Results could help remove one of the barriers to treatment scale up and bring new hope for people with Chagas disease
A two-week treatment course for adult patients with chronic Chagas disease showed, when compared to placebo, similar efficacy and significantly fewer side effects than the standard treatment duration of eight weeks, according to the results of a clinical trial in Bolivia led by DNDi.
El País [28 February 2019]
“La mujer que cambió la historia de los medicamentos” – “The woman who changed the history of medicines”
SciDev.Net [27 February 2019]
“Pocos medicamentos nuevos para enfermedades desatendidas” – “Few new treatments for neglected diseases”
Fexinidazole, the first all-oral treatment for both stages of HAT caused by T.b gambiense and DNDi’s first new chemical entity, was recommended by the European Medicines Agency in November and registered in Democratic Republic of Congo (DRC) in December 2018. The Phase II/III study on acoziborole opened new clinical sites in DRC and Guinea.
In Africa, results of a Phase III study on HIV/VL in Ethiopia showed high efficacy of a new combination therapy for co-infected patients, a Phase III study began to test new combination treatment for visceral leishmaniasis, and a Phase II study testing new treatments for PKDL started in Sudan. In Asia, the results of an infectivity study in Bangladesh confirmed that PKDL acts as a reservoir for leishmaniasis infection, with implications for elimination efforts across South Asia. In Latin America, the Brazilian Ministry of Health is reviewing its treatment policy to consider the adoption of AmBisome as the country’s first-line visceral leishmaniasis treatment.
A Phase II study of new benznidazole regimens was completed in 2018 with results coming in 2019. A Phase II study of fexinidazole, a new drug being tested for Chagas, completed patient recruitment in 2018. New diagnosis and treatment access projects were launched in Guatemala and Brazil, and the project in Colombia showed major increases in people tested in pilot areas.
Two Phase I studies in healthy volunteers for potentially macrofilaricidal drugs were successfully completed, for emodepside (Bayer) and the antibiotic TylAMac (AbbVie). Phase II studies are planned for sub-Saharan Africa.
The first-ever double-blind, randomized clinical trial for fungal mycetoma, underway in Sudan, had enrolled 84 patients by January 2019, the threshold for interim analysis. The primary objective of the study is to demonstrate the superiority of fosravuconazole over the current standard, itraconazole.
As development continues for a “4-in-1” fixed-dose combination (abacavir/lamivudine/ lopinavir/ritonavir) for young children, interim results of the LIVING study for an optimized “2-in-1” lopinavir/ritonavir paediatric formulation were released. The study – which enrolled over 1,000 children in sub-Saharan Africa – showed that 83% of children were virologically suppressed at 48 weeks, compared to 55% at the beginning of the study.
The first stage of the clinical trial in Malaysia and Thailand testing the ravidasvir/sofosbuvir combination showed excellent results in 301 chronically infected adults, as 97% of those enrolled were cured. Cure rates were notably high for the hardest-to-treat patients. Stage 2 of the study, to confirm the pangenotypic potential of the combination, has started.