%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Siddhivinayak Hirve, Axel Kroeger, Greg Matlashewski, Dinesh Mondal, Megha Raj Banjara, Pradeep Das, Ahmed Be-Nazir, Byron Arana, Piero Olliaro
Towards elimination of visceral leishmaniasis in the Indian subcontinent—Translating research to practice to public health
www.plosntds.org
www.plosntds.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 11 0 R/Contents 12 0 R/TrimBox[0 0 612 792]>>
endobj
11 0 obj
[13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R]
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref001)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref002)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref003)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref004)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref005)>>
endobj
18 0 obj
<>/Border[0 0 0]/A 19 0 R>>
endobj
19 0 obj
<>
endobj
12 0 obj
[20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R]
endobj
20 0 obj
<>stream
q
0.955 g
0 w
199.9998 582.9987 m
575.9997 582.9987 l
575.9997 343.9993 l
199.9998 343.9993 l
f*
0.45 0.36 0.35 0.01 k
575.9997 607.9986 m
199.9998 607.9986 l
199.9998 608.4986 l
575.9997 608.4986 l
f*
0.83 0.64 0.02 0 k
311.9811 289.9276 m
316.7433 289.9276 l
h
f*
347.9244 224.9008 m
352.6866 224.9008 l
h
f*
357.1087 224.9008 m
361.8709 224.9008 l
h
f*
203.4142 185.8961 m
208.1764 185.8961 l
h
f*
497.7638 146.948 m
502.526 146.948 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(environmental)Tj
6.4211 0 Td
(management)Tj
6.0035 0 Td
(as)Tj
1.2652 0 Td
(tools)Tj
2.3035 0 Td
(for)Tj
1.3785 0 Td
(integrated)Tj
4.613 0 Td
(vector)Tj
2.9122 0 Td
(managem)Tj
4.4101 0 Td
(ent)Tj
1.5934 0 Td
(in)Tj
0.9846 0 Td
(reducing)Tj
4.0043 0 Td
(sandfly)Tj
-35.8894 -1.474 Td
(density.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 666.4818 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions/significance)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 649.474 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(TDR's)Tj
2.9718 0 Td
(engagement)Tj
5.7171 0 Td
(with)Tj
1.9753 0 Td
(country)Tj
3.4672 0 Td
(policy)Tj
2.7451 0 Td
(makers,)Tj
3.7477 0 Td
(scientists,)Tj
4.5652 0 Td
(and)Tj
1.8619 0 Td
(clinicians)Tj
4.2192 0 Td
(in)Tj
0.9846 0 Td
(the)Tj
1.5934 0 Td
(development)Tj
-33.8485 -1.474 Td
(of)Tj
1.0443 0 Td
(effective)Tj
3.9088 0 Td
(diagnosis,)Tj
4.6607 0 Td
(treatment,)Tj
4.6847 0 Td
(case)Tj
2.3094 0 Td
(detection,)Tj
4.5116 0 Td
(and)Tj
1.8619 0 Td
(vector)Tj
2.9182 0 Td
(control)Tj
3.1867 0 Td
(represents)Tj
4.8935 0 Td
(an)Tj
1.3188 0 Td
(important)Tj
-35.2986 -1.468 Td
(example)Tj
3.9565 0 Td
(of)Tj
1.0443 0 Td
(TDR's)Tj
2.9719 0 Td
(stewardship)Tj
5.4962 0 Td
(toward)Tj
3.1927 0 Td
(the)Tj
1.5934 0 Td
(elimination)Tj
4.9293 0 Td
(of)Tj
1.0443 0 Td
(VL)Tj
1.4323 0 Td
(in)Tj
0.9846 0 Td
(the)Tj
1.5934 0 Td
(Indian)Tj
2.9122 0 Td
(subcontinent.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 209.9905 565.0015 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.137 0 Td
(summary)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 209.9905 546.9732 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Since)Tj
2.3584 0 Td
(the)Tj
1.4683 0 Td
(early)Tj
2.1543 0 Td
(days)Tj
1.9956 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(kala-azar)Tj
3.8324 0 Td
(elimination)Tj
4.8473 0 Td
(programme)Tj
4.9492 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(Indian)Tj
2.8857 0 Td
(subcontinent,)Tj
-29.4801 -1.2982 Td
(TDR)Tj
2.1883 0 Td
(has)Tj
1.542 0 Td
(engaged)Tj
3.5093 0 Td
(with)Tj
1.9956 0 Td
(national)Tj
3.5036 0 Td
(control)Tj
3.1237 0 Td
(and)Tj
1.7292 0 Td
(research)Tj
3.5602 0 Td
(institutions)Tj
4.7679 0 Td
(to)Tj
1.0261 0 Td
(conduct)Tj
3.4753 0 Td
(research)Tj
-30.4212 -1.2983 Td
(aimed)Tj
2.6928 0 Td
(at)Tj
0.9525 0 Td
(informing)Tj
4.3029 0 Td
(country)Tj
3.3506 0 Td
(policy)Tj
2.6362 0 Td
(and)Tj
1.7291 0 Td
(practice)Tj
3.3789 0 Td
(to)Tj
1.0261 0 Td
(identify)Tj
3.2939 0 Td
(and)Tj
1.7291 0 Td
(treat)Tj
2.0466 0 Td
(cases)Tj
2.2223 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0262 0 Td
(prevent)Tj
-32.1163 -1.2982 Td
(transmission)Tj
5.3631 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(infection.)Tj
4.0138 0 Td
(This)Tj
1.9899 0 Td
(includes)Tj
3.5433 0 Td
(the)Tj
1.4683 0 Td
(evaluation)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(rK39)Tj
2.2167 0 Td
(rapid)Tj
2.3357 0 Td
(diagnostic)Tj
-30.2681 -1.304 Td
(test)Tj
1.6043 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(diagnosis)Tj
3.9628 0 Td
(of)Tj
1.0148 0 Td
(VL,)Tj
1.6781 0 Td
(the)Tj
1.4683 0 Td
(clinical)Tj
3.0728 0 Td
(development)Tj
5.4141 0 Td
(and)Tj
1.7291 0 Td
(evaluation)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(first-line)Tj
3.6396 0 Td
(treat-)Tj
-31.8101 -1.2982 Td
(ments)Tj
2.6702 0 Td
(\(miltefosine)Tj
5.0116 0 Td
(and)Tj
1.7291 0 Td
(liposomal)Tj
4.1272 0 Td
(amphotericin)Tj
5.6239 0 Td
(B\),)Tj
1.3663 0 Td
(the)Tj
1.4684 0 Td
(generation)Tj
4.507 0 Td
(of)Tj
1.0148 0 Td
(evidence-based)Tj
6.3156 0 Td
(tools)Tj
-33.8341 -1.2983 Td
(for)Tj
1.3889 0 Td
(early)Tj
2.1487 0 Td
(detection)Tj
3.9344 0 Td
(and)Tj
1.7348 0 Td
(complete)Tj
3.8778 0 Td
(clinical)Tj
3.0727 0 Td
(management)Tj
5.4368 0 Td
(of)Tj
1.0148 0 Td
(VL,)Tj
1.6781 0 Td
(the)Tj
1.4684 0 Td
(evaluation)Tj
4.3653 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(cost)Tj
-32.6038 -1.3039 Td
(effectiveness)Tj
5.2043 0 Td
(of)Tj
1.0148 0 Td
(indoor)Tj
2.948 0 Td
(residual)Tj
3.3789 0 Td
(spraying,)Tj
3.8664 0 Td
(insecticide-treated)Tj
7.5798 0 Td
(bed)Tj
1.6781 0 Td
(nets,)Tj
2.075 0 Td
(insecticide-impreg-)Tj
-27.7453 -1.2983 Td
(nated)Tj
2.4547 0 Td
(durable)Tj
3.2542 0 Td
(wall)Tj
1.8312 0 Td
(linings,)Tj
3.1521 0 Td
(and)Tj
1.7291 0 Td
(environmental)Tj
6.1114 0 Td
(vector)Tj
2.6986 0 Td
(management)Tj
5.4312 0 Td
(as)Tj
1.0148 0 Td
(tools)Tj
2.1429 0 Td
(for)Tj
1.3833 0 Td
(integrated)Tj
-31.2035 -1.2982 Td
(vector)Tj
2.6985 0 Td
(management.)Tj
5.6636 0 Td
(The)Tj
1.7801 0 Td
(interaction)Tj
4.6092 0 Td
(and)Tj
1.7291 0 Td
(interdependence)Tj
6.9165 0 Td
(between)Tj
3.5262 0 Td
(implementation)Tj
-26.9232 -1.304 Td
(research,)Tj
3.7813 0 Td
(technical)Tj
3.8155 0 Td
(advice,)Tj
2.9763 0 Td
(partnership,)Tj
5.0797 0 Td
(and)Tj
1.7291 0 Td
(policy)Tj
2.6362 0 Td
(is)Tj
0.8504 0 Td
(yet)Tj
1.3946 0 Td
(another)Tj
3.3335 0 Td
(example)Tj
3.549 0 Td
(of)Tj
1.0148 0 Td
(TDR's)Tj
2.7609 0 Td
(stew-)Tj
-32.9213 -1.2982 Td
(ardship)Tj
3.2258 0 Td
(contribution)Tj
5.295 0 Td
(and)Tj
1.7292 0 Td
(empowerment)Tj
6.0547 0 Td
(toward)Tj
3.0444 0 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8473 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(Indian)Tj
2.8856 0 Td
(subconti-)Tj
-31.0391 -1.2983 Td
(nent.)Tj
2.2677 0 Td
(Continuing)Tj
4.8585 0 Td
(investment)Tj
4.6658 0 Td
(in)Tj
1.0318 0 Td
(translational)Tj
5.2157 0 Td
(research)Tj
3.5546 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(bench)Tj
2.6475 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(bedside)Tj
3.2598 0 Td
(to)Tj
-33.6753 -1.3039 Td
(public)Tj
2.7099 0 Td
(health,)Tj
2.9026 0 Td
(established)Tj
4.5978 0 Td
(jointly)Tj
2.8006 0 Td
(by)Tj
1.1792 0 Td
(national)Tj
3.5036 0 Td
(control)Tj
3.1238 0 Td
(programmes,)Tj
5.5332 0 Td
(academics,)Tj
4.558 0 Td
(and)Tj
1.7292 0 Td
(TDR)Tj
-32.6379 -1.2983 Td
(coordinators,)Tj
5.5672 0 Td
(is)Tj
0.8503 0 Td
(imperative)Tj
4.4958 0 Td
(to)Tj
1.0261 0 Td
(block)Tj
2.3981 0 Td
(transmission)Tj
5.3688 0 Td
(and)Tj
1.7291 0 Td
(prevent)Tj
3.2542 0 Td
(a)Tj
0.6576 0 Td
(resurgence)Tj
4.5581 0 Td
(of)Tj
1.0148 0 Td
(VL)Tj
1.4513 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-33.4089 -1.2982 Td
(future.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 320.9952 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 303.9874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(About)Tj
2.7439 0 Td
(147)Tj
1.6441 0 Td
(million)Tj
3.1237 0 Td
(people)Tj
2.8516 0 Td
(are)Tj
1.4514 0 Td
(at)Tj
0.9524 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(visceral)Tj
3.1975 0 Td
(leishmaniasis)Tj
5.5388 0 Td
(\(VL\),)Tj
2.3584 0 Td
(also)Tj
1.7688 0 Td
(known)Tj
3.0047 0 Td
(as)Tj
1.0148 0 Td
(kala-azar)Tj
3.8325 0 Td
(in)Tj
-36.2152 -1.2982 Td
(the)Tj
1.4683 0 Td
(Southeast)Tj
4.0705 0 Td
(Asian)Tj
2.5172 0 Td
(region)Tj
2.8006 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7801 0 Td
(largely)Tj
2.863 0 Td
(localized)Tj
3.7077 0 Td
(geographic)Tj
4.6204 0 Td
(endemicity,)Tj
4.8983 0 Td
(anthroponotic)Tj
-30.3305 -1.2983 Td
(transmission)Tj
5.3631 0 Td
(with)Tj
1.9955 0 Td
(humans)Tj
3.4413 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(only)Tj
1.9786 0 Td
(host)Tj
1.9105 0 Td
(reservoir,)Tj
3.9969 0 Td
(the)Tj
1.4683 0 Td
(sandfly)Tj
3.0841 0 Td
(species)Tj
/F10 1 Tf
2.9933 0 Td
[()4()10()4()20()4()12()11()11()6()11( )-4(\n)]TJ
5.709 0 Td
[()16()6(\r)2()2()]TJ
-34.4237 -1.3039 Td
[()7()10()4()8(\n)]TJ
/F5 1 Tf
1.9842 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(only)Tj
1.9729 0 Td
(vector)Tj
2.6986 0 Td
(species,)Tj
3.2258 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(availability)Tj
4.5297 0 Td
(of)Tj
1.0148 0 Td
(effective)Tj
3.5093 0 Td
(tools)Tj
2.1429 0 Td
(for)Tj
1.3833 0 Td
(diagnosis)Tj
3.9572 0 Td
(and)Tj
1.7348 0 Td
(treat-)Tj
-33.8341 -1.2983 Td
(ment,)Tj
2.5341 0 Td
(all)Tj
1.1452 0 Td
(supported)Tj
4.2746 0 Td
(by)Tj
1.1792 0 Td
(historical)Tj
3.9231 0 Td
(evidence)Tj
3.7134 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(disappearance)Tj
5.9017 0 Td
(of)Tj
1.0148 0 Td
(VL)Tj
1.4513 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(1970s)Tj
2.4832 0 Td
(following)Tj
-32.9837 -1.2982 Td
(insecticide)Tj
4.4503 0 Td
(spraying)Tj
3.6397 0 Td
(for)Tj
1.3833 0 Td
(malaria)Tj
3.2258 0 Td
(eradication,)Tj
4.9492 0 Td
(favour)Tj
2.8007 0 Td
(the)Tj
1.474 0 Td
(elimination)Tj
4.8472 0 Td
(of)Tj
1.0148 0 Td
(VL)Tj
1.4513 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
-33.613 -1.3039 Td
(problem)Tj
3.6056 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4627 0 Td
(Indian)Tj
2.88 0 Td
(subcontinent)Tj
5.4708 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(3)Tj
0 g
(].)Tj
1.2529 0 Td
(The)Tj
1.7801 0 Td
(World)Tj
2.829 0 Td
(Health)Tj
2.914 0 Td
(Organization)Tj
5.5162 0 Td
(\(WHO\))Tj
3.3732 0 Td
(has)Tj
1.5363 0 Td
(identi-)Tj
-34.9112 -1.2983 Td
(fied)Tj
1.7234 0 Td
(leishmaniasis)Tj
5.5389 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(category)Tj
3.6 0 Td
(I)Tj
0.5613 0 Td
(disease)Tj
3.016 0 Td
(\(emerging)Tj
4.3427 0 Td
(and)Tj
1.7347 0 Td
(uncontrolled\),)Tj
5.9584 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(World)Tj
2.8403 0 Td
(Health)Tj
-34.1799 -1.2983 Td
(Assembly)Tj
4.0761 0 Td
(\(WHA\))Tj
3.3166 0 Td
(43.18)Tj
2.347 0 Td
(resolution)Tj
4.2803 0 Td
(recognizes)Tj
4.422 0 Td
(leishmaniasis)Tj
5.5389 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(major)Tj
2.6078 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(concern)Tj
-33.6413 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.5987 0 Td
(In)Tj
1.1112 0 Td
(2005,)Tj
2.347 0 Td
(the)Tj
1.4684 0 Td
(Ministers)Tj
4.0138 0 Td
(of)Tj
1.0148 0 Td
(Health)Tj
2.914 0 Td
(of)Tj
1.0148 0 Td
(Bangladesh,)Tj
4.9946 0 Td
(India,)Tj
2.5625 0 Td
(and)Tj
1.7291 0 Td
(Nepal)Tj
2.5795 0 Td
(affirmed)Tj
3.6397 0 Td
(strong)Tj
2.7666 0 Td
(political)Tj
-33.7547 -1.2983 Td
(commitment)Tj
5.4424 0 Td
(through)Tj
3.4469 0 Td
(intercountry)Tj
5.2611 0 Td
(cooperation)Tj
5.023 0 Td
(and)Tj
1.7291 0 Td
(crossborder)Tj
4.9549 0 Td
(collaboration)Tj
5.5162 0 Td
(to)Tj
1.0261 0 Td
(eliminate)Tj
3.9458 0 Td
(VL)Tj
-36.3455 -1.2982 Td
(by)Tj
1.1792 0 Td
(2015)Tj
2.1259 0 Td
(by)Tj
1.1792 0 Td
(reducing)Tj
3.7758 0 Td
(incidence)Tj
4.0705 0 Td
(to)Tj
1.0261 0 Td
(less)Tj
1.6101 0 Td
(than)Tj
2.0296 0 Td
(1)Tj
0.6973 0 Td
(per)Tj
1.5307 0 Td
(10,000)Tj
2.8233 0 Td
(population)Tj
4.5921 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(upazila,)Tj
3.2881 0 Td
(administra-)Tj
-32.3487 -1.2983 Td
(tive)Tj
1.661 0 Td
(block,)Tj
2.6249 0 Td
(and)Tj
1.7348 0 Td
(district)Tj
3.0331 0 Td
(levels)Tj
2.3754 0 Td
(in)Tj
1.0318 0 Td
(Bangladesh,)Tj
4.9946 0 Td
(India,)Tj
2.5625 0 Td
(and)Tj
1.7291 0 Td
(Nepal,)Tj
2.8063 0 Td
(respectively)Tj
4.8812 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7802 0 Td
(WHA)Tj
2.6362 0 Td
(60.13)Tj
-35.4555 -1.3039 Td
(resolution)Tj
4.2746 0 Td
(in)Tj
1.0374 0 Td
(2007)Tj
2.1203 0 Td
(mandates)Tj
4.0706 0 Td
(WHO)Tj
2.6985 0 Td
(to)Tj
1.0262 0 Td
(update)Tj
2.948 0 Td
(the)Tj
1.4683 0 Td
(epidemiological)Tj
6.565 0 Td
(evidence)Tj
3.7077 0 Td
(and)Tj
1.7348 0 Td
(take)Tj
1.8709 0 Td
(the)Tj
1.4683 0 Td
(lead)Tj
-34.9906 -1.2983 Td
(in)Tj
1.0318 0 Td
(providing)Tj
4.1498 0 Td
(technical)Tj
3.8098 0 Td
(assistance)Tj
4.1329 0 Td
(in)Tj
1.0375 0 Td
(initiation,)Tj
4.1442 0 Td
(maintenance,)Tj
5.6182 0 Td
(and)Tj
1.7291 0 Td
(expansion)Tj
4.2917 0 Td
(of)Tj
1.0148 0 Td
(leishmaniasis)Tj
-30.9598 -1.2982 Td
(control)Tj
3.118 0 Td
(programmes.)Tj
5.5389 0 Td
(The)Tj
1.7801 0 Td
(VL)Tj
1.4514 0 Td
(elimination)Tj
4.8472 0 Td
(framework,)Tj
4.8415 0 Td
(further)Tj
3.0274 0 Td
(updated)Tj
3.4809 0 Td
(in)Tj
1.0318 0 Td
(2012,)Tj
2.3471 0 Td
(identifies)Tj
3.8948 0 Td
(early)Tj
-35.3591 -1.3039 Td
(diagnosis)Tj
3.9571 0 Td
(and)Tj
1.7291 0 Td
(complete)Tj
3.8778 0 Td
(case)Tj
1.8652 0 Td
(management,)Tj
5.6579 0 Td
(effective)Tj
3.5093 0 Td
(disease)Tj
3.0217 0 Td
(and)Tj
1.7291 0 Td
(vector)Tj
2.6986 0 Td
(surveillance,)Tj
5.1703 0 Td
(social)Tj
-33.2161 -1.2983 Td
(mobilization)Tj
5.3007 0 Td
(and)Tj
1.7291 0 Td
(building)Tj
3.5773 0 Td
(partnerships,)Tj
5.4425 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(and)Tj
1.7292 0 Td
(operational)Tj
4.7735 0 Td
(research)Tj
3.5603 0 Td
(as)Tj
1.0148 0 Td
(5)Tj
0.6916 0 Td
(key)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 183.2882 23.6976 re
W* n
q
183.2315 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
163.5591 34.9228 m
317.7071 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Neglected)Tj
4.6417 0 Td
(Tropical)Tj
3.7135 0 Td
(Disease)Tj
3.5433 0 Td
(s)Tj
0.7158 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8197 0 Td
(1/journal.pn)Tj
5.1237 0 Td
(td.00058)Tj
3.8197 0 Td
(89)Tj
0 g
2.0905 0 Td
(October)Tj
3.7276 0 Td
(12,)Tj
1.5874 0 Td
(2017)Tj
23.6128 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
21 0 obj
<>stream
endstream
endobj
22 0 obj
<>stream
endstream
endobj
23 0 obj
<>stream
endstream
endobj
24 0 obj
<>stream
endstream
endobj
25 0 obj
<>stream
endstream
endobj
26 0 obj
<>stream
BT
66.402 0 Td
(25)Tj
ET
Q
endstream
endobj
27 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 28 0 R/Contents 29 0 R/TrimBox[0 0 612 792]>>
endobj
28 0 obj
[30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref006)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref007)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref008)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref009)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref010)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref011)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref012)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref012)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005889.ref015)>>
endobj
39 0 obj
<>/Border[0 0 0]/A 40 0 R>>
endobj
40 0 obj
<>
endobj
29 0 obj
[41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R]
endobj
41 0 obj
<>stream
q
0.83 0.64 0.02 0 k
378.7087 706.337 m
383.4709 706.337 l
h
f*
203.4142 667.3323 m
208.1764 667.3323 l
h
f*
422.1354 641.3102 m
426.8976 641.3102 l
h
f*
258.1795 602.3055 m
262.9417 602.3055 l
h
f*
406.9417 589.3228 m
416.4094 589.3228 l
h
f*
359.5465 550.3181 m
369.0709 550.3181 l
h
f*
302.0598 524.2961 m
311.5843 524.2961 l
h
f*
316.9134 498.3307 m
326.4378 498.3307 l
h
f*
331.5969 498.3307 m
341.1213 498.3307 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(strategies)Tj
3.9231 0 Td
(for)Tj
1.3833 0 Td
(achieving)Tj
4.0308 0 Td
(the)Tj
1.474 0 Td
(elimination)Tj
4.8472 0 Td
(goal)Tj
1.8709 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(A)Tj
0.9071 0 Td
(more)Tj
2.3414 0 Td
(recent)Tj
2.7099 0 Td
(initiative)Tj
3.7417 0 Td
(led)Tj
1.4173 0 Td
(WHO)Tj
2.7043 0 Td
(to)Tj
1.0204 0 Td
(define)Tj
2.6986 0 Td
(a)Tj
-36.6687 -1.3039 Td
(road)Tj
2.0579 0 Td
(map)Tj
1.9899 0 Td
(for)Tj
1.389 0 Td
(prevention,)Tj
4.8018 0 Td
(control,)Tj
3.3506 0 Td
(elimination,)Tj
5.0739 0 Td
(and)Tj
1.7292 0 Td
(eradication)Tj
4.7225 0 Td
(of)Tj
1.0147 0 Td
(17)Tj
1.1679 0 Td
(neglected)Tj
4.0025 0 Td
(tropical)Tj
3.2825 0 Td
(dis-)Tj
-34.5824 -1.2982 Td
(eases,)Tj
2.4491 0 Td
(including)Tj
4.0421 0 Td
(VL,)Tj
1.6781 0 Td
(by)Tj
1.1793 0 Td
(2030)Tj
2.1203 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(step)Tj
1.8198 0 Td
(toward)Tj
3.0387 0 Td
(achieving)Tj
4.0365 0 Td
(the)Tj
1.4684 0 Td
(Sustainable)Tj
4.7395 0 Td
(Development)Tj
5.6182 0 Td
(Goals)Tj
-33.8624 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.5987 0 Td
(The)Tj
1.7858 0 Td
(neglected)Tj
3.9968 0 Td
(tropical)Tj
3.2882 0 Td
(diseases)Tj
3.3789 0 Td
(road)Tj
2.0579 0 Td
(map)Tj
1.9899 0 Td
(is)Tj
0.8504 0 Td
(endorsed)Tj
3.9061 0 Td
(by)Tj
1.1849 0 Td
(donor)Tj
2.6816 0 Td
(partners)Tj
3.5432 0 Td
(and)Tj
1.7292 0 Td
(stakeholders)Tj
-31.9916 -1.2983 Td
(who)Tj
1.9388 0 Td
(have)Tj
2.058 0 Td
(pledged)Tj
3.3505 0 Td
(support)Tj
3.3222 0 Td
(to)Tj
1.0261 0 Td
(sustain)Tj
3.0161 0 Td
(national)Tj
3.5036 0 Td
(programmes,)Tj
5.5332 0 Td
(extend)Tj
2.9083 0 Td
(drugs)Tj
2.4718 0 Td
(and)Tj
1.7291 0 Td
(interventions,)Tj
-30.8577 -1.3039 Td
(and)Tj
1.7291 0 Td
(monitor)Tj
3.5376 0 Td
(progress)Tj
3.6 0 Td
(towards)Tj
3.4015 0 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8473 0 Td
(by)Tj
1.1848 0 Td
(2020)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
-20.6757 -1.2982 Td
(The)Tj
1.7858 0 Td
(decade)Tj
2.9763 0 Td
(following)Tj
3.9799 0 Td
(the)Tj
1.474 0 Td
(launch)Tj
2.9253 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(Regional)Tj
3.7361 0 Td
(Strategic)Tj
3.6736 0 Td
(Framework)Tj
4.8586 0 Td
(for)Tj
1.3833 0 Td
(VL)Tj
1.4513 0 Td
(Elimination)Tj
-31.9235 -1.2983 Td
(in)Tj
1.0318 0 Td
(2005)Tj
2.1146 0 Td
(has)Tj
1.5364 0 Td
(shown)Tj
2.8459 0 Td
(a)Tj
0.6463 0 Td
(substantial)Tj
4.4957 0 Td
(reduction)Tj
4.1102 0 Td
(of)Tj
1.0092 0 Td
(incident)Tj
3.5206 0 Td
(VL)Tj
1.4456 0 Td
(cases)Tj
2.2167 0 Td
(by)Tj
1.1792 0 Td
(more)Tj
2.3358 0 Td
(than)Tj
2.0239 0 Td
(75%)Tj
1.9219 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4626 0 Td
(Indian)Tj
-34.9282 -1.3039 Td
(subcontinent)Tj
5.4765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
1.6044 0 Td
(Only)Tj
2.2166 0 Td
(16)Tj
1.1679 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(140)Tj
1.6498 0 Td
(previously)Tj
4.3483 0 Td
(endemic)Tj
3.6567 0 Td
(upazilas)Tj
3.4185 0 Td
(in)Tj
1.0375 0 Td
(Bangladesh)Tj
4.7679 0 Td
(reported)Tj
3.6566 0 Td
(an)Tj
-35.4838 -1.2983 Td
(incidence)Tj
4.0705 0 Td
(rate)Tj
1.7461 0 Td
(above)Tj
2.5455 0 Td
(the)Tj
1.474 0 Td
(elimination)Tj
4.8472 0 Td
(target)Tj
2.5115 0 Td
(in)Tj
1.0318 0 Td
(2013)Tj
2.126 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.0749 0 Td
(further)Tj
3.0274 0 Td
(down)Tj
2.4888 0 Td
(to)Tj
1.0261 0 Td
(2)Tj
0.6917 0 Td
(upazilas)Tj
3.4242 0 Td
(in)Tj
1.0318 0 Td
(2015.)Tj
-34.1175 -1.2983 Td
(An)Tj
1.4513 0 Td
(independent)Tj
5.2724 0 Td
(assessment)Tj
4.6148 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(national)Tj
3.5036 0 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8472 0 Td
(programme)Tj
4.9493 0 Td
(indicates)Tj
3.7701 0 Td
(that)Tj
1.7801 0 Td
(all)Tj
1.1452 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-36.2832 -1.3039 Td
(12)Tj
1.1678 0 Td
(previously)Tj
4.354 0 Td
(endemic)Tj
3.651 0 Td
(districts)Tj
3.3959 0 Td
(in)Tj
1.0375 0 Td
(Nepal)Tj
2.5738 0 Td
(have)Tj
2.0636 0 Td
(achieved)Tj
3.702 0 Td
(VL)Tj
1.4514 0 Td
(elimination)Tj
4.8472 0 Td
(since)Tj
2.245 0 Td
(2013)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(main-)Tj
-34.3386 -1.2982 Td
(tained)Tj
2.7155 0 Td
(the)Tj
1.474 0 Td
(elimination)Tj
4.8472 0 Td
(status)Tj
2.5002 0 Td
(thereafter)Tj
4.0762 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.0806 0 Td
(Despite)Tj
3.2428 0 Td
(considerable)Tj
5.2611 0 Td
(progress)Tj
3.6 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.6519 0 Td
(declining)Tj
-32.1786 -1.2983 Td
(trend)Tj
2.3867 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(incident)Tj
3.5263 0 Td
(VL)Tj
1.4513 0 Td
(cases,)Tj
2.4491 0 Td
(90)Tj
1.1736 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(456)Tj
1.6441 0 Td
(endemic)Tj
3.6567 0 Td
(blocks)Tj
2.7609 0 Td
(\(20%\))Tj
2.6079 0 Td
(continue)Tj
3.7643 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(highly)Tj
-32.5868 -1.3039 Td
(endemic)Tj
3.651 0 Td
(for)Tj
1.3889 0 Td
(VL)Tj
1.4513 0 Td
(in)Tj
1.0375 0 Td
(India)Tj
2.3358 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.0749 0 Td
(On)Tj
1.5194 0 Td
(the)Tj
1.4683 0 Td
(other)Tj
2.3471 0 Td
(hand,)Tj
2.4831 0 Td
(new)Tj
1.8765 0 Td
(ecologic)Tj
3.481 0 Td
(niches)Tj
2.7722 0 Td
(of)Tj
1.0148 0 Td
(focal)Tj
2.1203 0 Td
(indigenous)Tj
-31.0221 -1.2983 Td
(transmission)Tj
5.3631 0 Td
(have)Tj
2.0579 0 Td
(emerged)Tj
3.6737 0 Td
(in)Tj
1.0375 0 Td
(hitherto)Tj
3.4412 0 Td
(nonendemic)Tj
5.2611 0 Td
(hilly)Tj
1.9615 0 Td
(areas)Tj
2.2394 0 Td
(of)Tj
1.0148 0 Td
(Nepal)Tj
2.5795 0 Td
(and)Tj
1.7291 0 Td
(Bhutan,)Tj
3.3619 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
-36.5553 -1.2982 Td
(in)Tj
1.0318 0 Td
(Bangladesh)Tj
4.7678 0 Td
(and)Tj
1.7348 0 Td
(Thailand)Tj
3.8154 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
-10.1536 -1.2983 Td
(Since)Tj
2.3584 0 Td
(2005,)Tj
2.3527 0 Td
(the)Tj
1.4684 0 Td
(Special)Tj
3.0047 0 Td
(Programme)Tj
4.9946 0 Td
(for)Tj
1.3833 0 Td
(Research)Tj
3.804 0 Td
(and)Tj
1.7348 0 Td
(Training)Tj
3.7304 0 Td
(in)Tj
1.0375 0 Td
(Tropical)Tj
3.5943 0 Td
(Diseases)Tj
3.5886 0 Td
(\(TDR\))Tj
-34.2479 -1.3039 Td
(has)Tj
1.542 0 Td
(coordinated)Tj
5.057 0 Td
(and)Tj
1.7291 0 Td
(financed)Tj
3.6793 0 Td
(research)Tj
3.5547 0 Td
(for)Tj
1.3889 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(new)Tj
1.8765 0 Td
(innovative)Tj
4.422 0 Td
(tools)Tj
2.143 0 Td
(to)Tj
1.0261 0 Td
(support)Tj
3.3166 0 Td
(the)Tj
-36.1585 -1.2983 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8472 0 Td
(initiative)Tj
3.7474 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(Indian)Tj
2.8856 0 Td
(subcontinent.)Tj
5.7033 0 Td
(TDR,)Tj
2.4151 0 Td
(in)Tj
1.0318 0 Td
(conjunction)Tj
5.0797 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(WHO)Tj
-33.1311 -1.2983 Td
(Neglected)Tj
4.1839 0 Td
(Tropical)Tj
3.5999 0 Td
(Disease)Tj
3.2258 0 Td
(group,)Tj
2.8347 0 Td
(has)Tj
1.542 0 Td
(worked)Tj
3.2315 0 Td
(in)Tj
1.0318 0 Td
(close)Tj
2.1827 0 Td
(coordination)Tj
5.4254 0 Td
(with)Tj
2.0013 0 Td
(academia,)Tj
4.2066 0 Td
(technical)Tj
-33.4656 -1.3039 Td
(and)Tj
1.7291 0 Td
(development)Tj
5.4084 0 Td
(partners,)Tj
3.7701 0 Td
(financial)Tj
3.6793 0 Td
(institutions,)Tj
4.9947 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(pharmaceutical)Tj
6.3666 0 Td
(industry)Tj
3.5773 0 Td
(to)Tj
1.0204 0 Td
(collabo-)Tj
-33.749 -1.2982 Td
(rate)Tj
1.7461 0 Td
(with)Tj
1.9956 0 Td
(regional)Tj
3.4866 0 Td
(researchers,)Tj
4.9322 0 Td
(national)Tj
3.5036 0 Td
(disease)Tj
3.0217 0 Td
(control)Tj
3.1181 0 Td
(programmes,)Tj
5.5389 0 Td
(and)Tj
1.7291 0 Td
(policy)Tj
2.6362 0 Td
(makers)Tj
3.1238 0 Td
(to)Tj
-34.8319 -1.2983 Td
(identify)Tj
3.2938 0 Td
(gaps)Tj
1.9956 0 Td
(in)Tj
1.0374 0 Td
(knowledge,)Tj
4.7679 0 Td
(define)Tj
2.6985 0 Td
(research)Tj
3.5547 0 Td
(needs,)Tj
2.7326 0 Td
(and)Tj
1.7291 0 Td
(generate)Tj
3.6056 0 Td
(evidence)Tj
3.7134 0 Td
(to)Tj
1.0261 0 Td
(inform)Tj
3.0217 0 Td
(the)Tj
-33.1764 -1.3039 Td
(Regional)Tj
3.7303 0 Td
(Technical)Tj
4.1272 0 Td
(Advisory)Tj
3.8495 0 Td
(Group)Tj
2.8573 0 Td
(tasked)Tj
2.7609 0 Td
(with)Tj
1.9956 0 Td
(guiding)Tj
3.2881 0 Td
(the)Tj
1.4684 0 Td
(regional)Tj
3.4866 0 Td
(and)Tj
1.7291 0 Td
(national)Tj
3.5036 0 Td
(strategy,)Tj
-32.7966 -1.2983 Td
(policy,)Tj
2.8573 0 Td
(and)Tj
1.7347 0 Td
(public)Tj
2.7043 0 Td
(health)Tj
2.6815 0 Td
(practice)Tj
3.3789 0 Td
(for)Tj
1.3833 0 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8473 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(Indian)Tj
2.8856 0 Td
(subcontinent.)Tj
5.709 0 Td
(As)Tj
1.2642 0 Td
(countries)Tj
-33.4032 -1.2983 Td
(consolidate)Tj
4.7621 0 Td
(the)Tj
1.4684 0 Td
(gains)Tj
2.296 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(attack)Tj
2.6021 0 Td
(phase)Tj
2.4832 0 Td
(and)Tj
1.7291 0 Td
(transition)Tj
4.1216 0 Td
(to)Tj
1.0261 0 Td
(maintain)Tj
3.8381 0 Td
(the)Tj
1.4683 0 Td
(achievements,)Tj
5.8507 0 Td
(it)Tj
0.788 0 Td
(is)Tj
-36.1131 -1.2982 Td
(important)Tj
4.2802 0 Td
(to)Tj
1.0262 0 Td
(understand)Tj
4.7905 0 Td
(the)Tj
1.4683 0 Td
(lead)Tj
1.8482 0 Td
(coordination)Tj
5.4312 0 Td
(role)Tj
1.7631 0 Td
(of)Tj
1.0148 0 Td
(TDR)Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(WHO)Tj
2.6986 0 Td
(to)Tj
1.0261 0 Td
(drive)Tj
2.262 0 Td
(this)Tj
1.6781 0 Td
(elimina-)Tj
-33.2104 -1.3039 Td
(tion)Tj
1.8425 0 Td
(process.)Tj
-0.6463 -1.2983 Td
(Critical)Tj
3.1918 0 Td
(contributions)Tj
5.6522 0 Td
(by)Tj
1.1849 0 Td
(many)Tj
2.4774 0 Td
(stakeholders,)Tj
5.4198 0 Td
(including)Tj
4.0422 0 Td
(national)Tj
3.5036 0 Td
(and)Tj
1.7292 0 Td
(international)Tj
5.4141 0 Td
(actors,)Tj
-33.8114 -1.2983 Td
(have)Tj
2.0579 0 Td
(supported)Tj
4.2746 0 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8473 0 Td
(efforts)Tj
2.7552 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(Indian)Tj
2.8857 0 Td
(subcontinentranging)Tj
9.5016 0 Td
(from)Tj
2.2054 0 Td
(drug)Tj
2.1146 0 Td
(avail-)Tj
-34.5994 -1.3039 Td
(ability)Tj
2.6872 0 Td
(\(the)Tj
1.8028 0 Td
(AmBisome)Tj
4.6715 0 Td
(donation)Tj
3.8494 0 Td
(from)Tj
2.1997 0 Td
(Gilead)Tj
2.8289 0 Td
(Sciences)Tj
3.5546 0 Td
(managed)Tj
3.8665 0 Td
(by)Tj
1.1735 0 Td
(the)Tj
1.4627 0 Td
(WHO)Tj
2.6929 0 Td
(Neglected)Tj
4.1782 0 Td
(Tropi-)Tj
-34.9679 -1.2982 Td
(cal)Tj
1.3209 0 Td
(Disease)Tj
3.2258 0 Td
(group\))Tj
2.948 0 Td
(to)Tj
1.0261 0 Td
(support,)Tj
3.549 0 Td
(to)Tj
1.0205 0 Td
(deployment)Tj
4.9889 0 Td
(of)Tj
1.0148 0 Td
(interventions)Tj
5.5389 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(Bill)Tj
1.5591 0 Td
(&)Tj
0.9241 0 Td
(Melinda)Tj
3.5603 0 Td
(Gates)Tj
-34.35 -1.2983 Td
(Foundation)Tj
4.9095 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(United)Tj
3.0217 0 Td
(Kingdom)Tj
4.0308 0 Td
(government,)Tj
5.3008 0 Td
(and)Tj
1.7348 0 Td
(many)Tj
2.4774 0 Td
(others.)Tj
2.931 0 Td
(Many)Tj
2.5512 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2564 0 Td
(efforts)Tj
-33.4316 -1.3039 Td
(were)Tj
2.1203 0 Td
(to)Tj
1.0261 0 Td
(strengthen)Tj
4.4844 0 Td
(the)Tj
1.474 0 Td
(elimination)Tj
4.8472 0 Td
(programme)Tj
4.9436 0 Td
(and)Tj
1.7348 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(necessarily)Tj
4.5354 0 Td
(arise)Tj
2.0806 0 Td
(from)Tj
2.2054 0 Td
(research)Tj
-32.5642 -1.2983 Td
(needs)Tj
2.5058 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(national)Tj
3.5036 0 Td
(programmes.)Tj
5.5332 0 Td
(This)Tj
1.9899 0 Td
(paper)Tj
2.4831 0 Td
(focuses)Tj
3.1068 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(knowledge)Tj
4.541 0 Td
(generated)Tj
4.1329 0 Td
(through)Tj
-33.029 -1.2983 Td
(research,)Tj
3.7813 0 Td
(which)Tj
2.6476 0 Td
(in)Tj
1.0375 0 Td
(turn)Tj
1.9672 0 Td
(translated)Tj
4.1612 0 Td
(to)Tj
1.0262 0 Td
(practice)Tj
3.3788 0 Td
(and)Tj
1.7292 0 Td
(public)Tj
2.7099 0 Td
(health.)Tj
2.9026 0 Td
(The)Tj
1.7802 0 Td
(purpose)Tj
3.4469 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(paper)Tj
2.4831 0 Td
(is)Tj
0.8504 0 Td
(to)Tj
-36.5893 -1.3039 Td
(describe)Tj
3.5206 0 Td
(the)Tj
1.474 0 Td
(process)Tj
3.1804 0 Td
(of)Tj
1.0148 0 Td
(TDR's)Tj
2.7666 0 Td
(engagement)Tj
5.0683 0 Td
(with)Tj
2.0013 0 Td
(and)Tj
1.7291 0 Td
(contribution)Tj
5.2894 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(VL)Tj
1.457 0 Td
(elimination)Tj
4.8472 0 Td
(initia-)Tj
-34.8432 -1.2982 Td
(tive)Tj
1.661 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(Indian)Tj
2.8856 0 Td
(subcontinent.)Tj
5.7033 0 Td
(This)Tj
1.9899 0 Td
(paper)Tj
2.4831 0 Td
(is)Tj
0.8504 0 Td
(not)Tj
1.5704 0 Td
(intended)Tj
3.7871 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1508 0 Td
(a)Tj
0.652 0 Td
(comprehensive)Tj
6.2872 0 Td
(review)Tj
2.846 0 Td
(of)Tj
-35.3988 -1.2983 Td
(VL)Tj
1.4513 0 Td
(diagnosis)Tj
3.9571 0 Td
(and)Tj
1.7291 0 Td
(treatment)Tj
4.1386 0 Td
(or)Tj
1.0998 0 Td
(an)Tj
1.2019 0 Td
(evaluation)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(VL)Tj
1.457 0 Td
(elimination)Tj
4.8416 0 Td
(programme)Tj
4.9492 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(Indian)Tj
-34.1742 -1.2983 Td
(subcontinent.)Tj
5.7032 0 Td
(This)Tj
1.9843 0 Td
(paper)Tj
2.4888 0 Td
(brings)Tj
2.7382 0 Td
(together)Tj
3.532 0 Td
(and)Tj
1.7348 0 Td
(critically)Tj
3.651 0 Td
(analyses)Tj
3.4809 0 Td
(the)Tj
1.4683 0 Td
(context)Tj
3.1861 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(process)Tj
3.1861 0 Td
(of)Tj
-36.3512 -1.3039 Td
(translating)Tj
4.49 0 Td
(WHO)Tj
2.6986 0 Td
(TDRsupported)Tj
6.7577 0 Td
(research)Tj
3.5603 0 Td
(to)Tj
1.0205 0 Td
(effectively)Tj
4.2122 0 Td
(inform)Tj
3.0217 0 Td
(public)Tj
2.71 0 Td
(health)Tj
2.6758 0 Td
(practice)Tj
3.3789 0 Td
(and)Tj
-34.5257 -1.2983 Td
(policy)Tj
2.6362 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(model)Tj
2.7439 0 Td
(for)Tj
1.389 0 Td
(other)Tj
2.3471 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(initiatives.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(restricted)Tj
3.9855 0 Td
(our)Tj
1.6214 0 Td
(review)Tj
2.846 0 Td
(to)Tj
1.0261 0 Td
(include)Tj
3.1861 0 Td
(published)Tj
4.1216 0 Td
(and)Tj
1.7348 0 Td
(unpublished)Tj
5.1987 0 Td
(literature)Tj
3.8834 0 Td
(\(conference)Tj
4.9379 0 Td
(presen-)Tj
-34.1515 -1.3039 Td
(tations,)Tj
3.1577 0 Td
(meeting)Tj
3.4639 0 Td
(reports\))Tj
3.4129 0 Td
(on)Tj
1.2756 0 Td
(TDR-supported)Tj
6.5877 0 Td
(research)Tj
3.5603 0 Td
(that)Tj
1.7745 0 Td
(contributed)Tj
4.9209 0 Td
(directly)Tj
3.2314 0 Td
(or)Tj
1.0999 0 Td
(indirectly)Tj
-32.4848 -1.2982 Td
(towards)Tj
3.4015 0 Td
(the)Tj
1.4683 0 Td
(goal)Tj
1.8766 0 Td
(of)Tj
1.0148 0 Td
(VL)Tj
1.4513 0 Td
(elimination)Tj
4.8472 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(Indian)Tj
2.8857 0 Td
(subcontinent.)Tj
5.7032 0 Td
(We)Tj
1.6101 0 Td
(searched)Tj
3.7134 0 Td
(multiple)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 183.2882 23.6976 re
W* n
q
183.2315 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
163.5591 34.9228 m
317.7071 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Neglected)Tj
4.6417 0 Td
(Tropical)Tj
3.7135 0 Td
(Disease)Tj
3.5433 0 Td
(s)Tj
0.7158 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8197 0 Td
(1/journal.pn)Tj
5.1237 0 Td
(td.00058)Tj
3.8197 0 Td
(89)Tj
0 g
2.0905 0 Td
(October)Tj
3.7276 0 Td
(12,)Tj
1.5874 0 Td
(2017)Tj
23.6128 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
BT
66.402 0 Td
(25)Tj
ET
Q
endstream
endobj
51 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 53 0 R/Contents 54 0 R/TrimBox[0 0 612 792]>>
endobj
52 0 obj
<>
endobj
55 0 obj
<>
endobj
56 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Italic def
/FontType 1 def
/FontBBox {-31 -239 1041 750} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Italic) readonly def
/BaseFontName (TeX_CM_Maths_Italic) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤.vA2*Sr 2@Y0}Rcx,TX|ZP
;o<[1?
T<=qo:-62/]8~i wX?wJ`lLkI@EjYׅq5ڧHtvc6i 0M]YUN;M]ť0]z[{s1uO[6be#9k~d/YpMA.=뤎P\|W#?W$iz81ZL
Ңri^?WP]X A.@
z[
75y6k .U*3}hA\t&HW!Q
=+Г A 5