DNDi R&D Portfolio June 2019

45 projects and more than 20 new chemical entities, with over 20 ongoing clinical trials

Download R&D Portfolio June 2019

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Discovery iconDISCOVERY

Translation iconTRANSLATION

Development iconDEVELOPMENT

Implementation iconIMPLEMENTATION

 
Screening
Hit-to-lead
Lead optimization
Pre-clinical
Phase I
Phase IIa/ Proof-of-concept
Phase IIb/III
Registration
Treatment access

Sleeping sickness

   

starSCYX-1330682
SCYX-1608210

     

starAcoziborole

Fexinidazole for
T.b. rhodesiense

 

starFexinidazole for T.b. gambiense

Nifurtimox-eflornithine combination therapy (NECT)

Leishmaniasis

Screening

Leishmaniasis hit-to-lead

NTD Drug Discovery Booster hit-to-lead

Daiichi-Sankyo hit-to-lead

DNDI-5421
DNDI-5610

Aminopyrazoles

 CF series

Leishmaniasis L205 series

DNDI-5561

GSK3494245
DDD1305143

CpG-D35
for CL

DNDI-6148

DNDI-0690

GSK3186899
DDD853651

 

New CL combination

New treatments for PKDL

Miltefosine + paromomycin combination (Africa)

New VL
treatments
(Latin America)

New treatments for HIV/VL

SSG&PM
(East Africa)

New VL treatments
(South Asia)

Chagas disease

Screening

Chagas hit-to-lead

NTD Drug Discovery Booster hit-to-lead

Daiichi-Sankyo hit-to-lead

starChagas
C205 series

Biomarkers

 

Fexinidazole

New benznidazole regimens

 

Benznidazole
paediatric
dosage forms

Filarial diseases

Screening

 

starMacrofilaricide 3

 

starOxfendazole

starEmodepside

starTylAMac (ABBV-4083)

     

Mycetoma

           

Fosravuconazole

   

HIV

           

4-in-1
(ABC/3TC/
LPVr)

 

Super-booster therapy
for children with HIV/TB

2-in-1 LPV/r pellets and ABC/3TC or AZT/3TC

Hepatitis C

           

Ravidasvir + sofosbuvir

starRavidasvir

 

Malaria

Implementation transferred to the Medicines for Malaria Venture in 2015
               

Fixed-dose combination ASAQ

Fixed-dose combination ASMQ

star New Chemical Entity (NCE)

Completed Projects