- Target disease: Post Kala-Azar Dermal Leishmaniasis (PKDL) and Cutaneous Leishmaniasis (CL)
- Main partners (since project start): US Food and Drug Administration, USA; National Institutes of Health, USA; Ohio State University, USA; Nagasaki University, Japan; University of Osaka, Japan; GeneDesign Inc, Japan.
- Project Start: June 2014
- Funding: Global Health Innovative Technology (GHIT) Fund, Japan; Department for International Development (DFID), UK; Global Health Innovative Technology (GHIT) Fund, Japan; WHO-TDR (Demonstration Project).
CpG-D35 is being developed as a combination therapy for the treatment of complicated CL and post-kala-azar dermal leishmaniasis (PKDL) in partnership with GeneDesign. Leishmania parasites are able to persist in host cells by evading or exploiting immune, mechanisms. Modulating the immune response with CpG oligonucleotides may improve the effectiveness of chemotherapies.
Two studies, one in vitro and one in vivo, were initiated in 2016. The in vivo study aims to demonstrate if CpG-D35 – whether alone or in combination with antimonials chemotherapy – will lead to improved leishmania infection outcomes, compared with antimonials alone. Results are expected by mid-2017. The in vitro study aims to assess the stimulatory capability of CpG-D35 in both peripheral blood mononuclear cells and whole blood samples from patients with both CL, due to different leishmania species, and PKDL patients and to determine which host genes are modulated in these two conditions. Results are expected by the end of 2017.
Last update: August 2017