- Target disease: VL
- Main partners (since project start): Epichem, Australia; Fundaçao de Apoio Universidade Federale de Sao Paolo, Brazil; Centre for Drug Candidate Optimization, Monash University, Australia; TCG Lifesciences, India; Sandexis, UK; WuXi AppTech, China; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Belgium; London School of Hygiene and Tropical Medicine, UK; Griffith University, Australia; GlaxoSmithKline, Tres Cantos, Spain; Sanofi, France; Anacor Pharmaceuticals Inc., USA; Merck, USA; AstraZeneca, UK; AbbVie, USA.
- Project start: Ongoing
- Funding (since project start): Department for International Development (DFID), UK; Médecins Sans Frontières/Doctors without Borders, Dutch Ministry of Foreign Affairs (DGIS), The Netherlands; Federal Ministry of Education and Research (BMBF through KfW).
Hit-to-lead is a dynamic phase in the drug discovery cascade in which small molecule hits from high throughput screens are evaluated and undergo limited optimization to identify promising lead compounds. Series from a number of different partners have shown activity against L. donovani; work on these series to bring forward suitable candidates for lead optimization is on-going.
A number of pharmacokinetic and pharmacodynamic studies have been conducted in animal models of VL using existing and experimental drugs to build improved PK/PD models and ameliorate the translation of new drugs from discovery into clinical studies.
Last update: February 2017